Identification of a plane pollen lipid transfer protein (Pla a 3) and its immunological relation to the peach lipid‐transfer protein, Pru p 3

Abstract

Plane LTP is a major allergen in plane pollen-allergic patients with peach allergy recruited in the Mediterranean area. The results of histamine release tests and different IgE-binding profiles pointed towards the existence of species-specific IgE epitopes. Likewise, no general conclusion on the sensitizer could be made.

An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains

“…Although Iridaceae nsLTPs have not been studied, the nsLTP, Zea m 14, was localised in other monocotyledons, such as Zea mays, (Pastorello et al, 2003). The nsLTP of P. acerifolia, Pla a 3, is clearly implicated in plant food and pollen sensitisation and shows an amino acid sequence identity of 58.3% with Pru p 3 (Enrique et al, 2002;Lauer et al, 2007). This is in agreement with the moderate labelling obtained in P. acerifolia pollen grains.…”

“…It is assumed that nsLTPs from different species present diverse homologies. For example, the peach nsLTP, Pru p 3, has sequence similarities with Platanus and Artemisia pollen grains, plants which are botanically distant from the Rosaceae family Lauer et al, 2007). Nevertheless, undetectable crossreactivity between Pru p 3 and Par j 1, the major allergen of P. judaica, was found in allergic patients .…”

Molecular basis of allergen cross-reactivity: Non-specific lipid transfer proteins from wheat flour and peach fruit as models

“…Thus, wheat LTP, Tri a 14, has been recently characterized as a relevant inhalant allergen associated with baker's asthma (Palacin et al, 2007(Palacin et al, , 2009). An extensive cross-reactivity has been reported among allergenic nsLTPs from different plant foods, and between them and those from some pollen such as Artemisia and plane tree Lauer et al, 2007;Lombardero et al, 2004;Zuidmeer and van Ree, 2007). In this context, some baker's asthma patients sensitized to wheat Tri a 14 also recognize in vitro and in vivo peach Pru p 3, whereas no cross-reactivity between both allergens is found in other patients with similar allergic disorder (Palacin et al, 2007(Palacin et al, , 2009).…”

“…These allergens are usually associated with oral sensitization, although there is considerable evidence of other routes by which they can sensitize Lauer et al, 2007;Lombardero et al, 2004;Salcedo et al, 2007;Zuidmeer and van Ree, 2007). Thus, wheat LTP, Tri a 14, has been recently characterized as a relevant inhalant allergen associated with baker's asthma (Palacin et al, 2007(Palacin et al, , 2009).…”

“…nsLTPs have been considered as true food allergens, being primary sensitizers by the oral route, and proposed as plant food allergen model van Ree, 2002). However, an increasing body of experimental data point out to a complementary role as inhalant allergens, linked in some cases to plant food and pollen cross-reactions (Barber et al, 2008;Lauer et al, 2007;Zuidmeer and van Ree, 2007). In this context, wheat LTP Tri a 14 has been recently identified as a relevant allergen involved both in wheat food allergy and baker's asthma (Palacin et al, 2007(Palacin et al, , 2009Pastorello et al, 2007).…”