2022
DOI: 10.1002/slct.202103903
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Identification of a Potential mRNA‐based Vaccine Candidate against the SARS‐CoV‐2 Spike Glycoprotein: A Reverse Vaccinology Approach

Abstract: The emergence of the novel coronavirus (SARS-CoV-2) in December 2019 has generated a devastating global consequence which makes the development of a rapidly deployable, effective and safe vaccine candidate an imminent global health priority. The design of most vaccine candidates has been directed at the induction of antibody responses against the trimeric spike glycoprotein of SARS-CoV-2, a class I fusion protein that aids ACE2 (angiotensin-converting enzyme 2) receptor binding. A variety of formulations and v… Show more

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Cited by 11 publications
(13 citation statements)
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References 108 publications
(136 reference statements)
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“…7A) and PCA (principal component analysis) (Fig. 7B), both of which are also key indicators of the stability of proteins [54]. Taking together the resulting output of each post-simulation analysis over the 100 ns simulation period, CENP-I has been shown to be the most unstable of the four components of the subcomplex (Figs.…”
Section: Normal Mode Analysismentioning
confidence: 99%
“…7A) and PCA (principal component analysis) (Fig. 7B), both of which are also key indicators of the stability of proteins [54]. Taking together the resulting output of each post-simulation analysis over the 100 ns simulation period, CENP-I has been shown to be the most unstable of the four components of the subcomplex (Figs.…”
Section: Normal Mode Analysismentioning
confidence: 99%
“…Similarly, Durojaye et al [34] employed a reverse vaccinology approach for an mRNAbased vaccine candidate, focusing on the "YLQPRTFLL" peptide sequence (position 269-277). Identified as a potential B cell epitope with a high affinity for HLA*A-0201, this sequence was selected post antigenicity assessments.…”
Section: Overview Of Reverse Vaccinology In Mrna Vaccine Designmentioning
confidence: 99%
“…The study cited as Khan et al [31] employed Uniprot, an exhaustive compendium of protein-related data. Additionally, the Protein Data Bank (PDB) was cited as the data source in studies Bhattacharya et al [29], Durojaye et al [34].…”
Section: Retrieval Of Sequencementioning
confidence: 99%
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“…Furthermore, drugs that target 3CLpro are unlikely to be unaffected by possible spike protein mutations caused by immunological pressure following natural infection or vaccination. Hence, targeting 3CLpro by de novo drug design or drug-repurposing remains a viable therapeutic path to be explored 11 , 12 .…”
Section: Introductionmentioning
confidence: 99%