Identification of BAP1 mutation as a common mutation correlated with tumor mutation burden and immune infiltration in kidney renal clear cell carcinoma

Xu, Jin‐Zhou; Xia, Qi‐Dong; Lu, Junlin; Yang, Xiufen; Liu, Chen‐Qian; Sun, Jian‐Xuan; Liu, Cong; Hu, Jia; Wang, Shaogang

doi:10.1080/26895293.2022.2060310

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…For example, BAP1mutation commonly occurs in kidney renal clear cell carcinoma and is associated with tumor mutation burden and immune infiltration. 134 Further, inherited truncating mutations in BAP1 were found in families with members diagnosed with mesothelioma, uveal melanoma, or breast cancer. 125,135,136 Ubiquitin-specific protease 7 (USP7) is another DUB with vital effects in cancer biology.…”

Section: Deubiquitinasesmentioning

confidence: 97%

“…The observed contradiction is probably due to the mutations in BAP1 that reverse its tumor‐suppressive function. For example, BAP1mutation commonly occurs in kidney renal clear cell carcinoma and is associated with tumor mutation burden and immune infiltration 134 . Further, inherited truncating mutations in BAP1 were found in families with members diagnosed with mesothelioma, uveal melanoma, or breast cancer 125,135,136 …”

Section: The Role Of Ups Dysregulation In Tumorigenesismentioning

confidence: 99%

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Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

et al. 2023

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Regarding the multimechanistic nature of cancers, current chemo‐ or radiotherapies often fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur. Brain malignancies, particularly glioblastomas, are difficult‐to‐treat cancers due to their highly malignant and multidimensional biology. Unfortunately, patients suffering from malignant tumors often experience poor prognoses and short survival periods. Thus far, significant efforts have been conducted to discover novel and more effective modalities. To that end, modulation of the ubiquitin‐proteasome system (UPS) has attracted tremendous interest since it affects the homeostasis of proteins critically engaged in various cell functions, for example, cell metabolism, survival, proliferation, and differentiation. With their safe and multimodal actions, phytochemicals are among the promising therapeutic tools capable of turning the operation of various UPS elements. The present review, along with an updated outline of the role of UPS dysregulation in multiple cancers, provided a detailed discussion on the impact of phytochemicals on the UPS function in malignancies, especially brain tumors.

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Section: Deubiquitinasesmentioning

confidence: 97%

Section: The Role Of Ups Dysregulation In Tumorigenesismentioning

confidence: 99%

Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

et al. 2023

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“…The BAP1 mutations have a lower tumor mutation burden associated with poor prognosis, which worsens when it is considered in combination with mucin (MUC) 16 [ 68 ]. Some of the mucin family of proteins form a physical barrier that serves as the first line of defense for the epithelial layer surrounding the respiratory and gastrointestinal organs [ 69 ], a target for MM.…”

Section: The Connection Between Epi-mirna and Breast Cancer Gene 1-as...mentioning

confidence: 99%

Microbiomes, Epigenomics, Immune Response, and Splicing Signatures Interplay: Potential Use of Combination of Regulatory Pathways as Targets for Malignant Mesothelioma

Damane

Mkhize‐Kwitshana

Mehrotra³

et al. 2022

IJMS

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Malignant mesotheliomas (MM) are hard to treat malignancies with poor prognosis and high mortality rates. This cancer is highly misdiagnosed in Sub-Saharan African countries. According to literature, the incidence of MM is likely to increase particularly in low-middle-income countries (LMICs). The burden of asbestos-induced diseases was estimated to be about 231,000 per annum. Lack of awareness and implementation of regulatory frameworks to control exposure to asbestos fibers contributes to the expected increase. Exposure to asbestos fibers can lead to cancer initiation by several mechanisms. Asbestos-induced epigenetic modifications of gene expression machinery and non-coding RNAs promote cancer initiation and progression. Furthermore, microbiome–epigenetic interactions control the innate and adaptive immunity causing exacerbation of cancer progression and therapeutic resistance. This review discusses epigenetic mechanisms with more focus on miRNAs and their interaction with the microbiome. The potential use of epigenetic alterations and microbiota as specific biomarkers to aid in the early detection and/or development of therapeutic targets is explored. The advancement of combinatorial therapies to prolong overall patient survival or possible eradication of MM especially if it is detected early is discussed.

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Research Progress of BAP1 in Structure, Function, and Cancer

Dong

et al. 2023

PPL

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Cancer is an important chronic non-communicable disease that endangers human health, and has become the main cause of death of residents around the world in the 21st century. At present, most of the mature treatment methods stay at the level of cell and tissue, which is difficult to fundamentally solve the problem of cancer. Therefore, explaining the pathogenesis of cancer at the molecular level becomes the answer to the key problem of cancer regulation. BRCA-associated protein 1 (brca1-associated protein 1) is a kind of ubiquitination enzyme encoded by the BAP1 gene and composed of 729 amino acids. As a carcinogenic protein, BAP1 can affect the cancer cell cycle and proliferation capacity, mutation and deletion, for example, depending on catalytic activity, it participates in the regulation of intracellular function through transcription, epigenetic and DNA damage repair. This article mainly reviews the basic structure and function of BAP1 in cells, its role in cancer development and cancer-related mutants.

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Identification of BAP1 mutation as a common mutation correlated with tumor mutation burden and immune infiltration in kidney renal clear cell carcinoma

Cited by 3 publications

References 33 publications

Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

Microbiomes, Epigenomics, Immune Response, and Splicing Signatures Interplay: Potential Use of Combination of Regulatory Pathways as Targets for Malignant Mesothelioma

Research Progress of BAP1 in Structure, Function, and Cancer

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