Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro

Martínez-Montemayor, Michelle M.; Ling, Taotao; Suárez-Arroyo, Ivette J.; Ortíz-Soto, Gabriela; Santiago-Negrón, Camille L.; Lacourt-Ventura, Mercedes; Valentín-Acevedo, Aníbal; Lang, Walter H.; Rivas, Fátima

doi:10.3389/fphar.2019.00115

Cited by 72 publications

(46 citation statements)

References 64 publications

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“…Lingzhi mushrooms (Ganoderma species) have been generally acknowledged as a nutritional supplement across the world due to their association with long-term safety and the fact that they possess a vast array of medicinal properties. Various compounds that have exhibited inhibitory effects against HIV-1 protease activity have been identified from Ganoderma lucidum including ganolucidic acid A, 3β-5α-dihydroxy-6β-methoxyergosta-7,22-diene, ganoderic acid A-C, ganoderic acid β, ganodermanondiol, ganodermanontriol and lucidumol B [78][79][80]. Six colossolactones, ganomycin I, and ganomycin B isolated from G. colosum have displayed anti-HIV-1 protease activity [81,82].…”

Section: Hiv-1 Protease Inhibitors Isolated From Fungimentioning

confidence: 99%

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

et al. 2020

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The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.

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Section: Hiv-1 Protease Inhibitors Isolated From Fungimentioning

confidence: 99%

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

et al. 2020

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“…Briefly, the bioactive substances in the mushroom can be found in several of its parts, such as the mycelium and fruit body [4]. The most important types of these compounds are alkaloids, enzymes, glycoproteins, minerals, nucleotides, polysaccharides, proteins, steroids, triterpenes, and unsaturated fatty acids [39][40][41][42][43][44]. However, literature has reflected that the classification of the hydrophilic and hydrophobic properties of these compounds is useful to understand their effect as radioprotective compounds.…”

Section: Discussionmentioning

confidence: 99%

Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector

et al. 2020

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For millennia, naturopaths and physicians have used Ganoderma lucidum (reishi mushroom) for its diverse therapeutic properties, as recorded in the oldest Chinese herbal encyclopedia. Indeed, a radioprotective effect has been reported in the isolated components of its extracts. A systematic review and meta-analyses (PRISMA) was conducted in March 2020, searching databases including PubMed, Scopus, Embase, and Google Scholar, along with Clinical Trials. The inclusion criteria were ex vivo, in vitro, and in vivo studies, with full texts in English, conducted to determine the radioprotective benefits of G. lucidum, or reports in which ionizing radiation was used. From a total number of 1109 records identified, 15 full text articles were eligible, none of them were clinical trials. In vivo studies reveal the efficiency of G. lucidum aqueous extracts of polysaccharides and triterpenes in mice exposed to γ-rays. In plasmid, they can reduce radiation damage as an increment of the open circular form, as well as increase the DNA extension, as shown in vitro studies. Ex vivo studies conducted in human blood cells show the radioprotective effect of β-glucan of aqueous extract of G. lucidum, nevertheless, its implementation as radioprotector to humans is in need of further clinical research studies.

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“…7 Ergosterol peroxide has been reported as an anti-tumour agent, 8 and displays proapoptotic, 9 anti-inflammatory/immunosuppressive effects, 10 anti-mycobacterial, and anti-proliferative activity against cancer cell lines. 6, 11–13 Ergosterol peroxide triggers apoptosis, and modulates the cell cycle of cancer cell models in a dose-dependent manner. 8,13 We have shown that ergosterol peroxide displays anti-proliferative effects through G1 phase cell cycle arrest, apoptosis induction via caspase 3/7 activation, and PARP cleavage.…”

Section: Introductionmentioning

confidence: 99%

“…It decreases migratory and invasive effects of triple negative cancer cells while inhibiting the expression of total AKT1, AKT2, BCL-XL, Cyclin D1 and c-Myc in the tested breast cancer cells. 11…”

Section: Introductionmentioning

confidence: 99%