Identification of disability status in persons with multiple sclerosis by lower limb neuromuscular function – Emphasis on rate of force development

Taul-Madsen, Laurits; Riemenschneider, Morten; Jørgensen, MLK; Dalgas, Ulrik; Hvid, Lars G.

doi:10.1016/j.msard.2022.104082

Cited by 10 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to the collection of IMU data for MS monitoring, walking tasks have been used to collect EMG 72,[79][80][81][82][83] . Furthermore, popular were contraction and extensions tasks [84][85][86][87] as well as reaching tasks 88,89 . EMG sensors have also been used to investigate dysphagia [90][91][92] .…”

Section: Emgmentioning

confidence: 99%

“…However, no significant changes in muscle coactivation were found 84 . Force rate development has been identified as an essential correlate of disability status, possibly outweighing maximal muscle contraction 85 . Rehabilitation interventions have shown potential for enhancing maximal neural drive during knee extensions, as indicated by integrated EMG measures 86 .…”

Section: Emgmentioning

confidence: 99%

See 1 more Smart Citation

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Specht,

Jager,

Garbaya

et al. 2023

Preprint

View full text Add to dashboard Cite

In recent times, we have unequivocally witnessed a push towards digitising the healthcare system. Topics such as remote patient monitoring (RPM), digital health, and their use to monitor neurological disease progression have gained momentum and popularity. Notwithstanding the considerable advances that have been made in adopting such technologies and using them in the context of mental health or even a few neurodegenerative disease monitoring, they have not been widely used in the context of remote management and treatment of multiple sclerosis MS. In the same vein, given that (MS) is a very individualized disease to manage, there are numerous challenges yet opportunities associated with using digital health technologies for remote MS monitoring. This paper reviews the different research work and clinical attempts performed over the last decade (both home & hospital-based monitoring) en route to using digital health for MS monitoring and management. Similarly, this systematic review discusses the main challenges and barriers to translating that research from clinics into homes and highlights the opportunities in that context. Throughout this extensive review, we shine a light on various monitoring methods that hold the potential to be measured in a home environment, including electroencephalography (EEG) and evoked potentials (e.g., motor evoked potential (MEP), somatosensory evoked potentials (SSEP), and visual evoked potential (VEP)), electromyography (EMG), inertial measurement unit (IMU), and speech analysis. Combining such digital biomarkers could pave the way for developing a more personalised treatment for MS patients, thereby stopping its progression and avoiding silent MS disability. Adopting digital health for remote monitoring and management could also chart a route ahead for a new era of personalised medicine for MS patients and potentially other brain disorder patients.

show abstract

Section: Emgmentioning

confidence: 99%

Section: Emgmentioning

confidence: 99%

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Specht,

Jager,

Garbaya

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Para-meter wie z. B. Absprunggeschwindigkeit und Kraftentwicklungsrate geben Aufschluss über die Fähigkeit der schnellen Rekrutierung von motorischen Einheiten und Entladungsraten [16]. Der reaktive Wechsel zwischen exzentrischer zu konzentrischer Muskelaktivität kann mittels Reaktivkraftindex beurteilt werden, der neben der Sprunghöhe als zuverlässiger Indikator für die Sprungleistung fungiert.…”

Section: Sprunganalyse Als Grundlage Für Neurorehabilitative Therapie...unclassified

Sprunganalyse auf einer Kraftmessplatte – was sie über die MS verrät

Geßner¹,

Stölzer-Hutsch²,

Trentzsch³

et al. 2023

neuroreha

View full text Add to dashboard Cite

Eines der am häufigsten beeinträchtigten Funktionssysteme bei Multipler Sklerose (MS) ist die funktionelle Motorik. Bei detaillierter Betrachtung hochkomplexer Bewegungen zeigen sich schon frühzeitig im Erkrankungsverlauf unterschiedliche Defizite des neuromuskulären Zusammenspiels. Daher widmet sich das Zentrum für klinische Neurowissenschaften Dresden zur kinematischen und kinetischen Bewegungserfassung neben einer multidimensionalen Gangbeurteilung einer Analyse verschiedener Sprungvarianten bei Patienten mit Multipler Sklerose (PmMS).

show abstract

“…In summary, the muscle weakness experienced by PwMS is primarily due to disease-related compromised neural drive ( 44 , 55 , 58 , 72 ). During exercise, PwMS patients tend to display heightened fatigability compared to controls when the contractions are sustained and/or when disability status is higher and motor function is more likely to be impaired ( 31 , 44 , 73 ). When heightened fatigability is present in a task, VA is also more greatly impaired ( 46 , 47 , 74 ).…”

Section: Muscle Weakness and Motor Fatigabilitymentioning

confidence: 99%

How is neuromuscular fatigability affected by perceived fatigue and disability in people with multiple sclerosis?

Royer

Coates²,

Aboodarda³

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

Whereas fatigue is recognized to be the main complaint of patients with multiple sclerosis (PwMS), its etiology, and particularly the role of resistance to fatigability and its interplay with disability level, remains unclear. The purposes of this review were to (i) clarify the relationship between fatigue/disability and neuromuscular performance in PwMS and (ii) review the corticospinal and muscular mechanisms of voluntary muscle contraction that are altered by multiple sclerosis, and how they may be influenced by disability level or fatigue. Neuromuscular function at rest and during exercise are more susceptible to impairement, due to deficits in voluntary activation, when the disability is greater. Fatigue level is related to resistance to fatigability but not to neuromuscular function at rest. Neurophysiological parameters related to signal transmission such as central motor conduction time, motor evoked potentials amplitude and latency are affected by disability and fatigue levels but their relative role in the impaired production of torque remain unclear. Nonetheless, cortical reorganization represents the most likely explanation for the heightened fatigability during exercise for highly fatigued and/or disabled PwMS. Further research is needed to decipher how the fatigue and disability could influence fatigability for an ecological task, especially at the corticospinal level.

show abstract

Identification of disability status in persons with multiple sclerosis by lower limb neuromuscular function – Emphasis on rate of force development

Cited by 10 publications

References 57 publications

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Sprunganalyse auf einer Kraftmessplatte – was sie über die MS verrät

How is neuromuscular fatigability affected by perceived fatigue and disability in people with multiple sclerosis?

Contact Info

Product

Resources

About