Identification of Human Age Using Trace Element Concentrations in Hair and the Support Vector Machine Method

Lv, Jinmei; Wang, Wuyi; Zhang, Fengying; Krafft, Thomas; Yuan, Fuqing; Li, Yonghua

doi:10.1007/s12011-011-9007-z

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…In addition, certain essential elements, such as Mn, Se and Zn, are critical to the human metabolism and aging [ 8 , 9 ]. Lv et al reported that the higher Mn levels in the hair of centenarians were conducive to their long lifespan [ 10 ]. Besides, Se is associated with the prevention of some diseases such as cancer and Alzheimer's disease, and also has important impacts on longevity [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

Cai

Zhao

et al. 2016

Nutrients

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The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)—a famous longevous region—and elderly people aged 80–99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = −0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

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Section: Introductionmentioning

confidence: 99%

Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

Cai

Zhao

et al. 2016

Nutrients

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“…Therefore, Mn is known as an anti-aging element [33]. Lv J et al reported that the higher concentration of Mn in the hair of centenarians was conducive to their long lifespan [44].…”

Section: Discussionmentioning

confidence: 99%

A Correlation Between Diet and Longevity Characterization by Means of Element Profiles in Healthy People over 80 Years from a Chinese Longevous Region

Cai

Zhao

et al. 2015

Biol Trace Elem Res

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Monitoring the element concentrations in the human body is of critical importance for health and longevity. In order to explore the formation mechanism of longevity from the perspective of the body's element loads, this study investigated the prominent feature of element profiles in healthy people over 80 years from Bama County (China), a famous longevous region (LR). The element profiles in nails of elderly people from the LR and a non-longevous region were determined by inductively coupled plasma mass spectrometry, using orthogonal projections to latent structures discriminant analysis (OPLS-DA) for pattern recognition. As a result, four characteristic elements closely related to the healthy elderly people from LR, including Cr, Fe, Mn, and Co, were identified. The concentrations of Cr, Fe, Mn, and Co were significantly increased in the LR group (p < 0.05). The values of fold change of Cr, Fe, Mn, and Co were 3.00, 2.46, 2.24, and 2.21, respectively. These characteristic elements could provide an important material guarantee for health and longevity of elderly people in the LR. The further correlation analysis revealed significant positive correlations between the Sr (r = 0.886), Mn (r = 0.873), Ni (r = 0.786), and Co (r = 0.738) concentrations in nails of elderly people and those in drinking water. Furthermore, significant positive correlations were found between the Se (r = 0.940), Mn (r = 0.833), and Fe (r = 0.733) concentrations in nails and their dietary intake. Consequently, the observations suggested that diet could provide extraordinary reference information in terms of reflecting the feature of element profiles in healthy elderly people over 80 years from the LR.

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“… 2 Chemical elements in hair not only reflect chemical body pools but also reflect age-related changes in nutritional requirements and metabolic processes. 3 Children and adults had significant differences in elemental levels as found in a US population. 4 A study concerning a Sudanese population found different elemental levels across age groups.…”

Section: Introductionmentioning

confidence: 91%

Relationships Between Hair Chemical Elements and Nutritional Status in Oldest-Old and Centenarian Populations

Zhu¹,

Zhao²,

Ping³

et al. 2023

JMDH

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Background Hair chemical elements reflect physical condition over time. Collection, transporting, and storing hair is more convenient than handling blood. Hair elements show higher levels for a long time, which allows for more accurate and sensitive results than using blood. Studies explored the relationships between elements and age, without full consideration of nutritional status, in older people. This study explored the relationships between hair chemical elements and Geriatric Nutritional Risk Index (GNRI) in oldest-old and centenarian populations to provide an updated reference for nutritional evaluation of older people. Methods A total of 152 participants over 80 years old underwent home interviews and physical examinations. An inductively coupled plasma mass spectrometer was used to detect hair chemical elements. Results Women accounted for 77.0% of participants. Women had lower levels of zinc, and higher levels of selenium, manganese, lead, iron, and copper than men (P<0.05 for all). Ninety-two participants formed the 80–99 year group, and 60 participants formed the 100+ year group. Centenarians had lower levels of selenium, lead, iron, and copper than those aged 80–99 years (P<0.05 for all). Hair selenium levels were positively associated with GNRI (odds ratio: 11.55, 95% confidence interval: 3.42–19.68, P < 0.05) based on a multivariate linear regression analysis. Other chemical elements had no significant associations with GNRI based on a multivariate linear regression analysis. Conclusion Chemical elements and nutrient status were altered based on age and gender, and an association existed between hair selenium and nutritional status in older people. Chemical elements may influence and indicate nutritional status in older people.

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Identification of Human Age Using Trace Element Concentrations in Hair and the Support Vector Machine Method

Cited by 8 publications

References 28 publications

Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

A Correlation Between Diet and Longevity Characterization by Means of Element Profiles in Healthy People over 80 Years from a Chinese Longevous Region

Relationships Between Hair Chemical Elements and Nutritional Status in Oldest-Old and Centenarian Populations

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