2011
DOI: 10.2460/javma.238.4.463
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Identification of hypercoagulability in dogs with primary immune-mediated hemolytic anemia by means of thromboelastography

Abstract: Dogs with primary IMHA had hypercoagulability as demonstrated by thromboelastography at the time of initial diagnosis and prior to treatment. Such hypercoagulability may be a precursor to clinically evident thrombosis as a complication of the disease process.

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Cited by 83 publications
(88 citation statements)
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“…In veterinary medicine, TEM/TEG has been used to investigate different conditions of hypocoagulabilty [25,30], and hypercoagulabilty [21,23,31] in dogs and, to a lesser extent, in other species [20,24]. In bovine medicine, only one preliminary study on thromboelastometry [32] has been published to date.…”
Section: Discussionmentioning
confidence: 99%
“…In veterinary medicine, TEM/TEG has been used to investigate different conditions of hypocoagulabilty [25,30], and hypercoagulabilty [21,23,31] in dogs and, to a lesser extent, in other species [20,24]. In bovine medicine, only one preliminary study on thromboelastometry [32] has been published to date.…”
Section: Discussionmentioning
confidence: 99%
“…Risk factors inherent to IMHA are thrombocytopenia, increases in serum bilirubin concentrations, and hypoalbuminaemia, but treatment-related factors, such as glucocorticoid therapy, blood transfusion, and intravenous catheterization, may contribute as well (Klein et al 1989;McManus et al 2001;Carr et al 2002). Many dogs with IMHA can be considered hypercoagulable, based on thromboelastography recordings (Sinnott and Otto 2009;Kol and Borjesson 2010;Fenty et al 2011). P-selectin expression is considered to be a marker of activated platelets and is increased in dogs with IMHA (Weiss and Brazzell 2006;Ridyard et al 2010).…”
Section: Mortality and Thromboembolismmentioning
confidence: 99%
“…Definitions of hypercoagulability based on TEG variables have not yet been established for animals and numerous variables are used in different studies to define hypercoagulability, including maximal amplitude (MA) or global clot strength (G) alone or in combination with shortened reaction time (R), increased angle (α), or both 11, 12. Increased MA has been reported to be indicative of hypercoagulability in studies on animals,11, 13 and a single variable may be easier to interpret and may have greater clinical application. Evidence to support hemostatic alterations in spirocercosis includes three case reports of aorto‐iliac thromboemboli that were attributed to the migration of S. lupi larvae and associated vascular injury 14, 15, 16.…”
mentioning
confidence: 99%