Identification of key pathways and genes responsible for aggressive behavior

Uddin, Nasir; Hussain, Mushtaq; Rauf, Imran; Zaidi, Syed Farooq

doi:10.1016/j.compbiolchem.2020.107349

Cited by 1 publication

(1 citation statement)

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“…Like many other behaviors, aggression has a genetic basis [58]. For example, mutants (black) of D. melanogaster have reduced levels of β-alanine and were found to be less aggressive than wild-type flies [59].…”

Section: Discussionmentioning

confidence: 99%

Inbreeding-Driven Innate Behavioral Changes in Drosophila melanogaster

Amanullah

Arzoo

Aslam

et al. 2023

Biology

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Drosophila melanogaster has long been used to demonstrate the effect of inbreeding, particularly in relation to reproductive fitness and stress tolerance. In comparison, less attention has been given to exploring the influence of inbreeding on the innate behavior of D. melanogaster. In this study, multiple replicates of six different types of crosses were set in pair conformation of the laboratory-maintained wild-type D. melanogaster. This resulted in progeny with six different levels of inbreeding coefficients. Larvae and adult flies of varied inbreeding coefficients were subjected to different behavioral assays. In addition to the expected inbreeding depression in the-egg to-adult viability, noticeable aberrations were observed in the crawling and phototaxis behaviors of larvae. Negative geotactic behavior as well as positive phototactic behavior of the flies were also found to be adversely affected with increasing levels of inbreeding. Interestingly, positively phototactic inbred flies demonstrated improved learning compared to outbred flies, potentially the consequence of purging. Flies with higher levels of inbreeding exhibited a delay in the manifestation of aggression and courtship. In summary, our findings demonstrate that inbreeding influences the innate behaviors in D. melanogaster, which in turn may affect the overall biological fitness of the flies.

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Section: Discussionmentioning

confidence: 99%