2019
DOI: 10.1099/jgv.0.001288
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Identification of Marek’s disease virus genes associated with virulence of US strains

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Cited by 22 publications
(25 citation statements)
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“…Meq gene sequencing alone is known to be an insufficient method to include field strains into defined pathotypes; therefore, recently, the research is focusing on finding other genetic predictors of GaHV‐2 virulence using complete or targeted DNA sequencing (Dunn, Black Pyrkosz, Steep, & Cheng, ). This will provide a highly advantageous alternative to the classical ‘gold standard’ method of in vivo pathotyping (Witter et al, ), which requires the experimental infection of a large number of a specific type of chickens with standard GaHV‐2 prototype strains.…”
Section: Discussionmentioning
confidence: 99%
“…Meq gene sequencing alone is known to be an insufficient method to include field strains into defined pathotypes; therefore, recently, the research is focusing on finding other genetic predictors of GaHV‐2 virulence using complete or targeted DNA sequencing (Dunn, Black Pyrkosz, Steep, & Cheng, ). This will provide a highly advantageous alternative to the classical ‘gold standard’ method of in vivo pathotyping (Witter et al, ), which requires the experimental infection of a large number of a specific type of chickens with standard GaHV‐2 prototype strains.…”
Section: Discussionmentioning
confidence: 99%
“…MDV remains a threat to the poultry industry due to its evolution towards higher virulence [74], with virulence defined as the ability of the virus to replicate, cause disease, affect host defense, and increase spread [75]. The MDV-induced disease has dramatically changed since its discovery, and virus strains are currently classified into four pathotypes based on their pathogenicity in experimental infections in vaccinated and unvaccinated chickens [76,77].…”
Section: Evolution and Increase In Virulencementioning
confidence: 99%
“…During the evolution of MDV, specific changes in the genome have been documented that could contribute to the increase in virulence and allow the virus to overcome vaccine protection [74,84,94].…”
Section: Evolution and Increase In Virulencementioning
confidence: 99%
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