Identification of ovarian genes regulated by follicle-stimulating hormone (Fsh) in vitro during early secondary oocyte growth in coho salmon

Luckenbach, J. Adam; Yamamoto, Yoji; Guzmán, José Ignacio Navarro; Swanson, Penny

doi:10.1016/j.mce.2012.11.015

Cited by 22 publications

(22 citation statements)

References 68 publications

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“…Numerous other studies on a variety of species have produced similar data that are in agreement with the general scheme outlined above of the development of mechanisms in the previtellogenic secondary follicle that increase Fsh signaling to the ovarian follicle and the upregulation of steroidogenic capacity (Swanson et al, 2003;Kim et al, 2005;Molés et al, 2012;Guzmán et al, 2014) Transcript levels of a number of genes are linked to early secondary development of coho salmon follicles (Luckenbach et al, 2008). Genes associated with steroidogenic responsiveness and capacity of the follicle are regulated by Fsh in vitro (Luckenbach et al, 2011(Luckenbach et al, , 2013. Fsh induces a transient downregulation of fshr mRNA levels, and upregulation of the very low expression of Lh receptor (lhcgr) mRNA, the latter linked to the potential for Fsh to increase Lh responsiveness and the change in steroidogenic pathway in maturing follicles (see Section VI.F.i.…”

Section: Previtellogenic Secondary Follicle Developmentsupporting

confidence: 68%

Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development

et al. 2017

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The production of fertile eggs with the capacity to develop into larvae and subsequently into marketable fish is centrally important to the aquaculture industry. This entails not only the programmed production of large numbers of eggs, but also high quality eggs with the potential to support normal development and high survival of offspring to juvenile and later stages of development and growth. Numerous studies highlight the maternal contributions to the development of embryos, including transcripts that regulate cell division and determine oocyte polarity, pattern development during early and late embryonic stages and the transition from maternal to zygotic gene expression and translation. Since most fish embryos develop independently within an enclosed egg envelope, they rely on compounds deposited within the oocytes during their various stages of development. In addition to regulatory nucleic acids (maternal DNA and RNA), these include proteins and other compounds that contribute to the structure and function of the egg envelope and the bulk molecular cargo that will be used as a source of cellular energy and structural components for formation of embryos and larvae. These latter components notably include yolk lipids and proteins deposited during oocyte growth and water acquired at the same time and during cytoplasmic maturation. In this review we highlight recent advances made in revealing the transcripts deposited within the oocyte that contribute to the structural and morphological development of the embryo, and to the regulation of gene expression and translation during oocyte development. Significant advances have been made in revealing the molecular mechanisms of lipid accumulation and metabolism within the oocyte, the intricacies of yolk protein formation via endocytosis of multiple yolk precursor proteins by multiple oocyte receptors, and the complex machinery supporting massive accumulation of water by maturing oocytes of many species. Additionally, many advances have been made in our understanding of the endocrine regulation of all of these processes during oogenesis. We provide here an overview of recent advances in our knowledge on these various aspects of oogenesis and identify several gaps in our knowledge for future studies.

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Section: Previtellogenic Secondary Follicle Developmentsupporting

confidence: 68%

Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development

et al. 2017

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“…Additional PKA gene expression activity was associated with its two catalytic subunits that were able to transit to the CC nucleus. Several key genes were reported to be expressed downstream of this pathway, including HAS2, TNFAIP6, PTGS2, CYP19A1 and EGF-like factors ([75,91-96], recently reviewed in [20,21]). This transcriptional activity was mediated mainly – but not exclusively – through phosphorylation of CREB (CRE-binding protein) and therefore its binding to the CRE (cAMP-responsive-element) region in the promoter [97].…”

Section: Introductionmentioning

confidence: 99%

FSH in vitro versus LH in vivo: similar genomic effects on the cumulus

2013

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The use of gonadotropins to trigger oocyte maturation both in vivo and in vitro has provided precious and powerful knowledge that has significantly increased our understanding of the ovarian function. Moreover, the efficacy of most assisted reproductive technologies (ART) used in both humans and livestock species relies on gonadotropin input, mainly FSH and LH. Despite the significant progress achieved and the huge impact of gonadotropins, the exact molecular pathways of the two pituitary hormones, FSH and LH, still remain poorly understood. Moreover, these pathways may not be the same when moving from the in vivo to the in vitro context. This misunderstanding of the intricate synergy between these two hormones leads to a lack of consensus about their use mainly in vitro or in ovulation induction schedules in vivo. In order to optimize their use, additional work is thus required with a special focus on comparing the in vitro versus the in vivo effects. In this context, this overview will briefly summarize the downstream gene expression pathways induced by both FSH in vitro and LH in vivo in the cumulus compartment. Based on recent microarray comparative analysis, we are reporting that in vitro FSH stimulation on cumulus cells appears to achieve at least part of the gene expression activity after in vivo LH stimulation. We are then proposing that the in vitro FSH-response of cumulus cells have similitudes with the in vivo LH-response.

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“…Primers for qPCR analyses are listed in Table 2. The primers for several genes were the same as previously reported (Luckenbach et al, 2008b(Luckenbach et al, , 2013Yamamoto et al, 2011a).…”

Section: Quantitative Pcrmentioning

confidence: 99%

Alterations in gene expression during fasting-induced atresia of early secondary ovarian follicles of coho salmon, Oncorhynchus kisutch

Yamamoto

Luckenbach

Young

et al. 2016

Comparative Biochemistry and Physiology Part A: Molecular &

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Identification of ovarian genes regulated by follicle-stimulating hormone (Fsh) in vitro during early secondary oocyte growth in coho salmon

Cited by 22 publications

References 68 publications

Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development

Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development

FSH in vitro versus LH in vivo: similar genomic effects on the cumulus

Alterations in gene expression during fasting-induced atresia of early secondary ovarian follicles of coho salmon, Oncorhynchus kisutch

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