Identification of Pathogenic Strains within Serogroups of Yersinia pseudotuberculosis and the Presence of Non-Pathogenic Strains Isolated from Animals and the Environment.

Nagano, Tetsuji; Kiyohara, Tomoko; Suzuki, Kiyomi; Tsubokura, Misao; Otsuki, Koichi

doi:10.1292/jvms.59.153

Cited by 23 publications

(20 citation statements)

References 22 publications

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“…Although an estimation of the pathogenicity of groups 1 and 6 awaits confirmation from investigations of more cases of human infections, the pathogenicity of groups 4 and 5 was discussed. The distribution of group 4, which includes NMF serotypes O1b, -5a, -5b, -6, -7, -9, -10, -11, and -12 and which does not have pYV, among wild animals and environments in Japan suggests that the origin of this group is the Far East and that this group is nonpathogenic, thereby supporting the proposal that serotypes O6, -7, -9, -10, -11, and -12 are not lethal for mice (30). Group 5 contained NMF serotype O3 strains originating from patients and pigs and other members of livestock in Western countries (29) and from a patient and pigs in the Far East (44) but never from wild animals anywhere.…”

Section: Discussionmentioning

confidence: 56%

Geographical Heterogeneity between Far Eastern and Western Countries in Prevalence of the Virulence Plasmid, the SuperantigenYersinia pseudotuberculosis-Derived Mitogen, and the High-Pathogenicity Island amongYersinia pseudotuberculosisStrains

et al. 2001

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Yersinia pseudotuberculosis produces novel superantigenic toxins designated YPMa ( Y. pseudotuberculosis -derived mitogen), YPMb, and YPMc and has a pathogenicity island termed HPI (high-pathogenicity island) and R-HPI (the right-hand part of the HPI with truncation in its left-hand part) on the chromosome. Analysis of the distribution of these virulence factors allowed for differentiation of species Y. pseudotuberculosis into six subgroups, thus reflecting the geographical spread of two main clones: the YPMa + HPI − Far Eastern systemic pathogenic type belonging to serotypes O1b, -2a, -2b, -2c, -3, -4a, -4b, -5a, -5b, -6, -10, and UT (untypeable) and the YPMs − HPI + European gastroenteric pathogenic type belonging to serotypes O1a and -1b. The YPMa + HPI + pathogenic type belonging to serotypes O1b, -3, -5a, -5b, and UT and the YPMb + HPI − nonpathogenic type belonging to non-melibiose-fermenting serotypes O1b, -5a, -5b, -6, -7, -9, -10, -11, and -12 were prevalent in the Far East. The YPMc + R-HPI + European low-pathogenicity type belonging to non-melibiose-fermenting serotype O3 and the YPMs − HPI − pathogenic type belonging to 15 serotypes were found to be prevalent all over the world. This new information is useful for a better understanding of the evolution and spread of Y. pseudotuberculosis.

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Section: Discussionmentioning

confidence: 56%

Geographical Heterogeneity between Far Eastern and Western Countries in Prevalence of the Virulence Plasmid, the SuperantigenYersinia pseudotuberculosis-Derived Mitogen, and the High-Pathogenicity Island amongYersinia pseudotuberculosisStrains

et al. 2001

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“…pseudotuberculosis, a Gram-negative gastrointestinal pathogenic bacterium, causes self-limiting gastroenteritis and mesenteric lymphadenitis. Transmission between animals and humans is normally through the ingestion of contaminated food or faecal material (Nagano et al, 1997). Survival in acidic environments is important for infection, but the Y. pseudotuberculosis acid response is not well understood.…”

Section: Introductionmentioning

confidence: 99%

OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis

Wang

et al. 2009

Microbiology

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Yersinia pseudotuberculosis is an enteric bacterium which must overcome the acidic stress in host organs for successful colonization, but how this bacterium survives in acidic conditions remains largely unknown. In the present study, the importance of OmpR in acid survival of Y. pseudotuberculosis YpIII was confirmed by the fact that mutation of ompR (strain ΔompR) greatly reduced cell survival at pH 4.5 or lower. To characterize the regulatory role of OmpR in this acid survival process, proteomic analysis was carried out to compare YpIII at pH 7.0 and pH 4.5 with ΔompR at pH 7.0, and urease components were revealed to be the main targets for OmpR regulation. Addition of urea to the culture medium also enhanced acid survival of YpIII but not ΔompR and urease activity was significantly induced by acid in YpIII but not in ΔompR. Each of the seven components of the YpIII urease gene cluster was fused to a lacZ reporter and their expression was dramatically decreased in a ΔompR background; this supports the notion that OmpR positively regulates urease expression. Furthermore, gel shift analysis revealed that OmpR binds to the deduced promoter regions of three polycistronic transcriptional units (ureABC, ureEF and ureGD) in the urease cluster, suggesting that the regulation of OmpR to urease components is direct. Taken together, these data strongly suggest that OmpR activates urease expression to enhance acid survival in Y. pseudotuberculosis.

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“…All non-melibiose-fermenting strains of Y pseudotuberculosis O1c, O6, O9, O10, O11, O12 and are also non-pathogenic (33 …”

Section: Discussionmentioning

confidence: 99%

Characteristics and Pathogenicity of Non‐Melibiose‐Fermenting Strains of Yersinia pseudotuberculosis O3

Nagano

Ichimura

Haji

et al. 1997

Microbiology and Immunology

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The biological properties of non-melibiose-fermenting (NMF) strains of Yersinia pseudotuberculosis investigated.These strains were clearly distinguished from representative melibiose-fermenting (MF) strains of Y. pseudotuberculosis O3 by their pathogenicity in mice, sensitivity to some phages, production of catalase, restriction endonuclease analysis of virulence plasmid DNA with BamHI, detection of specific yersinia outer-membrane proteins with SDS-PAGE, antigenicity of the outer-membrane proteins and neutrophil resistance to phagocytosis. The pathogenicity of NMF strains was clearly less than that of MF strains. In addition, the resistance of NMF strains to phagocytosis and catalase activity was evidently weaker than that of MF strains. These results suggested that the difference of pathogenicity was due to the ability of catalase production. Although the relationship between the above characteristics and melibiose-fermentation was not analysed, the pathogenicity of Y. pseudotuberculosis O3 strains can probably be predicted by testing melibiose-fermentation and catalase production.

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Identification of Pathogenic Strains within Serogroups of Yersinia pseudotuberculosis and the Presence of Non-Pathogenic Strains Isolated from Animals and the Environment.

Cited by 23 publications

References 22 publications

Geographical Heterogeneity between Far Eastern and Western Countries in Prevalence of the Virulence Plasmid, the SuperantigenYersinia pseudotuberculosis-Derived Mitogen, and the High-Pathogenicity Island amongYersinia pseudotuberculosisStrains

Geographical Heterogeneity between Far Eastern and Western Countries in Prevalence of the Virulence Plasmid, the SuperantigenYersinia pseudotuberculosis-Derived Mitogen, and the High-Pathogenicity Island amongYersinia pseudotuberculosisStrains

OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis

Characteristics and Pathogenicity of Non‐Melibiose‐Fermenting Strains of Yersinia pseudotuberculosis O3

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