Identification of phytochemicals capping the exogenously biosynthesized silver nanoparticles by T. apollinea (Delile) DC. living plants and evaluation of their cytotoxic activity

Ali, Muna A.; Soliman, Sameh S. M.; Bajou, Khalid; El‐Keblawy, Ali; Mosa, Kareem A.

doi:10.1016/j.bcab.2022.102336

Cited by 4 publications

(1 citation statement)

References 70 publications

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“…Many studies have been carried out to explore the in vitro cytotoxic activity of the plant extract against several types of cancer. These studies have shown the anticancer properties of the extracts cancer cell lines (Ali et al, 2022;Mohamed et al, 2022). In this study, viability of the cells was evaluated in vitro by MTT assay.…”

Section: Cytotoxicity Of Hrgdmentioning

confidence: 99%

Cytotoxicity and acute toxicity evaluation of hydrogen-rich Gynostemma pentaphyllum Makino distillate

Kim

2022

JANS

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Hydrogen-rich Gynostemma pentaphyllum Makino distillate (HRGD) consists of Gynostemma pentaphyllum Makino steam distillate with hydrogen gas. Although both G. pentaphyllum Makino and hydrogen-rich water are well known for their biological and medical benefits, there is a lack of information on their safety and toxicity in vivo acute oral toxicity test and in vitro cytotoxicity method. The current study aimed to assess the cytotoxicity and acute oral toxicity of HRGD as a part of a safety evaluation using rat and human cell models. HRGD was administered orally once by gavage to male and female Sprague-Dawley rats at doses of 0, 2500, and 5000 mg/kg. Cytotoxicity assay was conducted in vitro at various concentrations in 10 different human normal and cancer cell lines; TK6 (human normal lymphomablastoid cells), Chang (human hepatic cells), 16HBE14o- (human bronchial epithelial cells), URotsa (human urothelium cells), MCF (human breast cancer cells), Hela (human cervical cancer cells), A375 (human malignant melanoma cells), HCT116 (human colon cancer cells), HepG2 (human liver cancer cells) and A549 (human non-small cell lung adenocarcinoma cells). From a 14-day study in rats, we observed no compound-related changes in mortality, clinical signs, body weight, food/water consumption, organ weight and gross pathology in all dose group. The result of in vivo acute toxicity shows that no observed adverse effect level of HRGD was below 5000 mg/kg for both sexes of rats, and the minimal lethal dose was considered to be more than 5000 mg/kg. HRGD also had no in vitro cytotoxicity against all tested cells. The present study data indicated that HRGD may contain bioactive compounds of potential therapeutic significance that are relatively safe from toxic effects.

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Section: Cytotoxicity Of Hrgdmentioning

confidence: 99%

Cytotoxicity and acute toxicity evaluation of hydrogen-rich Gynostemma pentaphyllum Makino distillate

Kim

2022

JANS

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Bio-Synthesized Silver Nanoparticles Using Cannabis Sativa Seed Extracts and Its Anticancer Effects

Yontar,

Çevik

2023

Plasmonics

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Electrospray deposited plant-based polymer nanocomposite coatings with enhanced antibacterial activity for Ti-6Al-4V implants

Yontar,

Çevik

2024

Progress in Organic Coatings

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Identification of phytochemicals capping the exogenously biosynthesized silver nanoparticles by T. apollinea (Delile) DC. living plants and evaluation of their cytotoxic activity

Cited by 4 publications

References 70 publications

Cytotoxicity and acute toxicity evaluation of hydrogen-rich Gynostemma pentaphyllum Makino distillate

Cytotoxicity and acute toxicity evaluation of hydrogen-rich Gynostemma pentaphyllum Makino distillate

Bio-Synthesized Silver Nanoparticles Using Cannabis Sativa Seed Extracts and Its Anticancer Effects

Electrospray deposited plant-based polymer nanocomposite coatings with enhanced antibacterial activity for Ti-6Al-4V implants

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