Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population

Chae, Soo-Cheon; Li, Chunshi; Kim, Ki Mo; Yang, Ji Yeon; Zhang, Qinggao; Lee, Yong-Chul; Yang, Yun-Sik; Chung, Hun‐Taeg

doi:10.1007/s10038-007-0123-8

Cited by 92 publications

(72 citation statements)

References 24 publications

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“…We previously reported that the SNPs or variations of the Tim-1 and IL-27 gene are associated with the susceptibility to asthma in a Korean population (16,17) as well that the SNP of Eotaxin-3 is associated with the total IgE level in the serum of asthma patients (18). However, our present study revealed that the SNPs of the TSLPR gene in asthma patients are not closely associated with the level of total serum IgE, the peripheral blood eosinophil counts (Table 2), the FVC and the FEV1 (Supplementary Table 3).…”

Section: Discussionmentioning

confidence: 99%

Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma

Kang²,

Chun³

et al. 2010

BMB Reports

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The present study aimed to investigate whether the polymorphisms in the TSLPR gene are associated with atopic and asthmatic disease in the Korean population. We identified eleven single nucleotide polymorphisms (SNPs) and two variation sites in the TSLPR gene, including the promoter region. The genotype and allele frequencies of g.33G＞C of the TSLPR gene in asthma patients were significantly different from the respective frequencies of the control group (P = 0.006 and 0.003, respectively). Our additional analysis showed that the genotype and allele frequencies of the g.33G＞C and g.19646A＞G of the TSLPR gene were significantly associated in the atopic asthma patients rather than in the non-atopic asthma patients (genotype frequencies; P = 0.0001 and 0.0003 respectively, allele frequencies; P = 0.0005 and 0.0001 in that order). Our results suggest that the SNPs of the TSLPR gene could be associated with the susceptibility to atopic asthma in the Korean population. [BMB reports 2010; 43(7): 499-505]

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Section: Discussionmentioning

confidence: 99%

Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma

Kang²,

Chun³

et al. 2010

BMB Reports

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“…For example, the association between IL-27p28 (-964 A/G) (rs153109) SNP and susceptibility to asthma and inflammatory bowel disease was found in Korean population (Chae et al, 2007;Li, Zhang et al, 2009). Also, it was suggested that IL-27p28 (-964A/G) polymorphism might enhance cancer risk in Chinese people (Xu et al, 2014).On the other hand, another study did not find any impact for IL-27p28 SNPs on the susceptibility to colorectal cancer (Huang, Wang et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Association of Interleukin-27 rs 153109 Single Nucleotide Polymorphism with Spontaneous Resolution of Hepatitis C Virus - Genotype 4a Infection in Egyptian Patients

Fawzy

Wahid²,

Nazmy³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: HCV is a major global health problem. IL-27 is a member of the IL-6/IL-12 cytokine family with a broad range of anti-inflammatory properties. Recent studies highlighted the effect of a SNP in the IL-27 promoter region on modulating the progression of infectious diseases and individual responses to therapy. Aim of the work: The present study investigated the potential role of (-964 A/G) SNP in the promoter region of IL-27p28 gene (alleles rs153109) on the outcome of HCV infection among genotype 4a infected patients. Materials and Methods: HCV genotyping confirmed that all of the HCV-infected patients had genotype 4a infection. Genomic DNA was extracted from 111 patients with chronic HCV infection, 42 spontaneous resolvers (SR) and 16 healthy controls. IL-27p28.rs153109 genotyping was assessed using PCR-RFLP then confirmed by DNA sequencing. Results: The frequency of IL-27-p28.rs153109AA, AG, and GG genotypes among chronically infected subjects were 74.8 %, 25.2%, and 0% while among the SR, they were 57.1%, 35.7%, and 7.14%, respectively. Our data show the unique presence of G/G genotype in the SR group (3 patients; 7.14%). Moreover, the "G" allele frequencies among chronic and resolved subjects were 12.6% and 25.0%, respectively (p=0.0136). Importantly, subjects with the GG genotype were more likely to clear their HCV infection than those with the AA genotype (p=0.0118). Conclusions: HCV genotype 4a subjects with the IL-27-p28.rs153109 A/G and G/G genotype were more likely to clear their HCV infection. Therefore, we propose IL-27p28.rs153109SNPas a genetic biomarker for predicting HCV infection outcome.

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“…The IL-27 and WSX-1 plays an important role in the down-regulation of airway hyper-reactivity and lung inflammation during the development of allergic asthma through its suppressive ef-fect on cytokine production [11]. We previously identified four SNPs in human IL-27p28 gene, and suggested that the IL-27p28 polymorphisms are possibly correlated with susceptibility to asthma [1]. In this study, we analyzed the genotype and allele frequencies at three SNPs of IL-27p28 gene between the allergic rhinitis patients and the healthy controls, and found that the genotype and allele frequencies of SNPs in IL-27p28 gene were not significantly different between the allergic rhinitis patients and the controls group (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…The entire coding regions of IL-27P28, including 1.9 kb promoter regions, were partially amplified with using GeneAmp PCR system 9700 thermocycler (PE Applied Biosystem, USA) and three primer pairs [1]. The PCR was carried out in a total reaction volume of 20 μl containing 50 ng genomic DNA, 0.5 μM primers, 0.2 mM dNTP, 1.…”

Section: Polymerase Chain Reaction (Pcr)mentioning

confidence: 99%

Human IL-27p28 Gene Polymorphisms are Associated with the Serum Total IgE Levels of Allergic Rhinitis Patients

2009

Journal of Life Science

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Interleukin 27 (IL-27) was discovered as a heterodimeric cytokine of the IL-12 family, and is composed of two subunits -Epstein-Barr virus induced gene 3 (EBI3) and p28. It acts as a versatile cytokine in the early regulation of Th1 initiation and in the negative regulation of the Th2 factor GATA binding protein 3 (GATA-3). This cytokine is mediated by the IL-27 receptor (WSX-1), which is highly expressed on CD4 + T lymphocytes and NK cells. We previously identified four polymorphisms in the human IL-27p28 gene and suggested that the polymorphism of IL-27p28 is associated with susceptibility to asthma. To determine whether these IL-27p28 SNPs are associated with susceptibility to allergic rhinitis, the genotype and allele frequencies of IL-27p28 SNPs were analyzed between allergic rhinitis patients and healthy controls. Although the genotype and allele frequencies of IL-27p28 SNPs in allergic rhinitis patients were not significantly different from those of the control group, there was a suggestive difference (P=0.037) between these groups in total serum IgE levels in the g.2905T>G SNP of the IL-27p28 gene. Our result implies that the g.2905T>G SNP of the IL-27p28 gene might have an affect on IgE production in allergic rhinitis patients.

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Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population

Cited by 92 publications

References 24 publications

Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma

Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma

Association of Interleukin-27 rs 153109 Single Nucleotide Polymorphism with Spontaneous Resolution of Hepatitis C Virus - Genotype 4a Infection in Egyptian Patients

Human IL-27p28 Gene Polymorphisms are Associated with the Serum Total IgE Levels of Allergic Rhinitis Patients

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