Identification of polypeptide components of adenovirus type 12 tumor antigen from productively and abortively infected cells and from tumor cells

Adenovirus type 12-transformed rat embryo brain and rat liver epithelial cell lines: adenovirus type 12 genome content and viral protein expression

“…In all adenoviruses investigated so far, the transforming gene region appears to correspond to the early region 1 (El), which maps between approximately 1 and 11% of the adenovirus genome (11-13, 29, 34). The identification of the adenovirus type 12 (Ad-12) protein(s) specified by the transforming gene region and responsible for transformation have so far been contradictory (1, 2,4,7,15,21,25,26,30,35,37). It is possible that some of the apparent differences in these results are due to the many different tissue culture systems used for Ad-12 transformation, such as primary embryo or adult cultures, or established cell lines, derived from different rodent species.…”