Identification of Prognostic and Predictive Biomarkers and Druggable Targets among 205 Antioxidant Genes in 21 Different Tumor Types via Data-Mining

Özenver, Nadire; Efferth, Thomas

doi:10.3390/pharmaceutics15020427

Cited by 2 publications

(1 citation statement)

References 76 publications

(87 reference statements)

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“…Due to these characteristics, ATPase activity may be brought back to normal levels, which would then allow the cell to function normally. These bioactive components are essential for controlling cellular processes and may be able to reverse cellular malfunction [30].…”

Section: Effect Of Membrane Bound Enzymes and Tumor Markersmentioning

confidence: 99%

Biochemical and Histoarchitectural Evaluation of 4-Vinylcyclohexane Induced Ovarian Cancer Against Alpinia Purpurata (Vieill). K. Schum

CHITHAMONY,

PALNIRAJAN,

RAJU

et al. 2023

Preprint

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Objective Alpinia purpurata is being studied for its potential to treat various conditions, including diabetes, arthritis, and tuberculosis. This research explores the impact of Alpinia purpurata (Vieill). K. Schum on ovarian cancer induced by 4-vinyl cyclohexane in Wistar albino rats.Materials and methods Five sets of 100-120g Wistar albino rats were assembled. Group 1 was the control group. Group 2 received intraperitoneal 4-vinyl cyclohexane (80 mg/kg) for one month. For two months, Group 3 was given A. purpurata leaf extract (200 mg/kg) orally. Cisplatin (5 mg/kg) intraperitoneal twice per week for two months was given to Group 4 as a standard drug. For two months, Group 5 acquired daily oral A. purpurata leaf extract (200 mg/kg). The rats were euthanized after the experiment under light chloroform anesthesia. Ovary and liver samples were obtained for lipid peroxidation, anti-oxidants, membrane-bound enzymes, tumor indicators, and histological investigation.Results Over a 60-day period, rats were given an ethyl acetate extract of A. purpurata at a dose of 200 mg/kg, which lead to in a substantial (p < 0.05) increase in body protein content, as well as enzyme levels. Furthermore, the use of the ethyl acetate extract significantly (p < 0.05) recovered the altered lipid peroxidation activities in the ovarian tissues of both control and experimental rats to near-normal levels. These data imply that the extract has the capacity to quench free radicals, indicating possible anticancer effects.Conclusion The results suggested that, the ethyl acetate extract of A. purpurata exhibited significant antitumor activity on ovarian cancer bearing rats.

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Section: Effect Of Membrane Bound Enzymes and Tumor Markersmentioning

confidence: 99%