2018
DOI: 10.18632/oncotarget.24963
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Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library

Abstract: The present study was planned to identify novel serum antibody markers for digestive organ cancers. We have used screening by phage expression cloning and identified novel fourteen antigens in this experiment. The presence of auto-antibodies against these antigens in serum specimens was confirmed by western blotting. As for auto-antibodies against fourteen antigens, AlphaLISA (amplified luminescence proximity homogeneous assay) assay was performed in the sera of gastrointestinal cancers patients to confirm the… Show more

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Cited by 29 publications
(30 citation statements)
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“…Therefore, FIRΔexon2 Abs with anti‐p53 Abs or CEA improves the specificity and sensitivity for screening ESCCs. Further prospective multi‐institutional studies comparing the sensitivity and specificity of this combinational detection approach will be required …”
Section: Discussionmentioning
confidence: 99%
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“…Therefore, FIRΔexon2 Abs with anti‐p53 Abs or CEA improves the specificity and sensitivity for screening ESCCs. Further prospective multi‐institutional studies comparing the sensitivity and specificity of this combinational detection approach will be required …”
Section: Discussionmentioning
confidence: 99%
“…Prior to development, highly malignant tumors can induce necrosis, leading to the exposure of intracellular antigenic proteins to plasma. Therefore, using combinational Ab detection approaches could allow for the precise early detection of tumors . In this study, we explored and examined 5 SEREX antigen markers for improved efficiency in diagnosing ESCC.…”
Section: Discussionmentioning
confidence: 99%
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