Identify aberrant white matter microstructure in ASD, ADHD and other neurodevelopmental disorders: A meta-analysis of diffusion tensor imaging studies

Zhao, Yilu; Yang, Li; Gong, Gaolang; Cao, Qingjiu; Liu, Jing

doi:10.1016/j.pnpbp.2021.110477

Cited by 50 publications

(46 citation statements)

References 130 publications

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“…The measure of FA, representing white matter integrity, is more sensitive than structural MRI metrics ( 33 ). DTI can detect and quantify subtle abnormalities of white matter before those are detectable by conventional structural MRI scans ( 30 ). Therefore, these findings might serve as imaging biomarkers for early diagnosis, monitoring disease progression, and response to therapy of brain disorders ( 46 – 48 ).…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion tensor imaging (DTI) is a noninvasive MRI method that can be used to detect microstructural alterations of the white matter, which cannot be revealed by conventional structural MRI scan ( 30 , 31 ). The integrity of nerve fibers can be measured by the parameter of fractional anisotropy (FA), which indicates the strength and direction of water molecules’ motion within the nerve fibers ( 32 ).…”

Section: Introductionmentioning

confidence: 99%

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Differences in structural connectivity between diabetic and psychological erectile dysfunction revealed by network-based statistic: A diffusion tensor imaging study

Chen

Xiao-hong

et al. 2022

Front. Endocrinol.

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IntroductionType 2 diabetes mellitus (T2DM) has been found to be associated with abnormalities of the central and peripheral vascular nervous system, which were considered to be involved in the development of cognitive impairments and erectile dysfunction (ED). In addition, altered brain function and structure were identified in patients with ED, especially psychological ED (pED). However, the similarities and the differences of the central neural mechanisms underlying pED and T2DM with ED (DM-ED) remained unclear.MethodsDiffusion tensor imaging data were acquired from 30 T2DM, 32 ED, and 31 DM-ED patients and 47 healthy controls (HCs). Then, whole-brain structural networks were constructed, which were mapped by connectivity matrices (90 × 90) representing the white matter between 90 brain regions parcellated by the anatomical automatic labeling template. Finally, the method of network-based statistic (NBS) was applied to assess the group differences of the structural connectivity.ResultsOur NBS analysis demonstrated three subnetworks with reduced structural connectivity in DM, pED, and DM-ED patients when compared to HCs, which were predominantly located in the prefrontal and subcortical areas. Compared with DM patients, DM-ED patients had an impaired subnetwork with increased structural connectivity, which were primarily located in the parietal regions. Compared with pED patients, an altered subnetwork with increased structural connectivity was identified in DM-ED patients, which were mainly located in the prefrontal and cingulate areas.ConclusionThese findings highlighted that the reduced structural connections in the prefrontal and subcortical areas were similar mechanisms to those associated with pED and DM-ED. However, different connectivity patterns were found between pED and DM-ED, and the increased connectivity in the frontal–parietal network might be due to the compensation mechanisms that were devoted to improving erectile function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differences in structural connectivity between diabetic and psychological erectile dysfunction revealed by network-based statistic: A diffusion tensor imaging study

Chen

Xiao-hong

et al. 2022

Front. Endocrinol.

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“…Autism is currently treated as a type of disability in which autistic people have problems with understanding and establishing social contacts. Traditional psychiatry treats the autism spectrum as a neurodevelopmental disorder [ 1 ]. Such an approach, although justified from the point of view of neurobiology, is strongly stigmatizing [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Disability is a transactional category, to a large extent culturally conditioned, which develops at the intersection of biological phenomena and their social connotations. For example, autism may be considered as a manifestation of neurodiversity, not as a manifestation of pathology [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Depression and Perceived Stress among Parents of Autistic and Non-Autistic Children—The Role of Loneliness

Sipowicz

Pietras

Podlecka

et al. 2022

IJERPH

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Having an autistic child significantly impairs the functioning of the family, including the wellbeing of the parents. The aim of this study was to assess whether loneliness mediates the relationship between perceived stress and the severity of depressive symptoms in the studied sample of parents. This cross-sectional study involved 39 parents of autistic children and 45 parents of non-autistic children. They completed a set of tests: a survey on sociodemographic and clinical data and psychometric questionnaires, i.e., Beck Depression Inventory II (BDI), De Jong Gierveld Loneliness Scale (DJGLS), and Perceived Stress Questionnaire (KPS). A rise in external and intrapsychic stress, independently, was linked to a rise in the severity of depressive symptoms. The severity of depression, loneliness and stress was higher among parents of autistic children compared with parents of non-autistic children. Intrapsychic stress exhibited an indirect effect through loneliness on the worsening of depressive symptoms.

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“…Neuroimaging studies exploring DTI measures in patients with ADHD compared to typical development controls discovered some WM structures associated with the disorder, where the most robust findings are specific regions in the corpus callosum (Albajara Sáenz et al, 2019;Y. Zhao et al, 2022).…”

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confidence: 99%

White Matter microstructure effect in ADHD: a two-sample mendelian randomization study

Tavares

Carpena

Vitola

et al. 2022

Preprint

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Introduction: Genome Wide Association Studies (GWAS) revealed the highly polygenic architecture of Attention-Deficit/Hyperactivity Disorder (ADHD) and highlighted the contribution of common variants related to brain development and function. In parallel, several imaging studies attempted to discover disorder-related brain structures, with some significant findings concerning white matter. Two-sample mendelian randomization (2SMR) is a powerful tool to evaluate causality between two phenotypes using summary statistics data. We aimed to investigate a possible causal relationship between white matter genetically predicted variation and ADHD diagnosis through 2SMR. Methods: A unidirectional two-sample MR analysis was performed based on summary statistics of GWAS between 22 different white matter (WM) mean fractional anisotropy measures and ADHD. We used 4 different MR approaches, considering IVW random effects as the main analysis, followed by several sensitivity analyses. Linkage Disequilibrium Score Regression (LDSC) was evaluated in the same set of samples to corroborate the direction of associations. Results and Discussion: Our most consistent finding across MR and LDSC approach, following the sensitivity analyses, indicate that the decreased WM microstructure integrity of the fornix stria terminalis (FXSTivw beta:-0.266 SE:0.083 pFDR: 0.021) genetic liability has a causal influence on ADHD diagnosis. The FXST is formed by connection fibers inside the limbic system, which is crucial to emotional processing, learning, and memory, functions usually impaired in ADHD. Therefore, this study increases knowledge concerning ADHD neurobiology and provides novel evidence of the causal effect of WM integrity in the limbic system, which could contribute to the advances in additional diagnostic tools as well as pharmacological brain structure targets.

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Identify aberrant white matter microstructure in ASD, ADHD and other neurodevelopmental disorders: A meta-analysis of diffusion tensor imaging studies

Cited by 50 publications

References 130 publications

Differences in structural connectivity between diabetic and psychological erectile dysfunction revealed by network-based statistic: A diffusion tensor imaging study

Differences in structural connectivity between diabetic and psychological erectile dysfunction revealed by network-based statistic: A diffusion tensor imaging study

The Association between Depression and Perceived Stress among Parents of Autistic and Non-Autistic Children—The Role of Loneliness

White Matter microstructure effect in ADHD: a two-sample mendelian randomization study

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