Identify the Early Predictor of Mortality in Patients with Acute Paraquat Poisoning

Wang, Jun; Jiang, Xinrui; Lu, Geng; Zhou, Jiawei; Kang, Jian; Zhang, Jinsong

doi:10.1155/2020/8894180

Cited by 16 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PQ intoxication leads to a large amount of deaths, whose mortality rate is as high as 60%~80% [21]. The kidney is also a major target organ after PQ intoxication apart from the 10 Mediators of Inflammation lung.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

Zheng

Zhao

Dong

et al. 2021

Mediators of Inflammation

View full text Add to dashboard Cite

Paraquat (PQ) can cause multiorgan failure including acute kidney injury (AKI). Our prior study showed that Toll-interacting protein (TOLLIP) protected against PQ-induced acute lung injury. However, the role of TOLLIP in PQ-induced AKI remains undefined. This study was aimed at understanding the role and mechanism of TOLLIP in AKI. Six-eight-week-old male Wistar rats were intraperitoneally injected with 25 mg/kg PQ to induce AKI for 24 h in vivo. HK-2 cells were treated with 300 μM PQ for 24 h to induce cellular injury in vitro or 300 μM PQ and 5 μM nuclear factor-κB (NF-κB) inhibitor BAY11-7082 for 24 h. Rats were infected with adenovirus carrying TOLLIP shRNA via tail vein injection and HK-2 cells with adenovirus carrying TOLLIP shRNA or TOLLIP 48 h before PQ exposure. Results showed that TOLLIP and Toll-like receptor 2/4 (TLR2/4) expressions were boosted in the kidney after PQ intoxication. The toxic effect of PQ on the kidney and HK-2 cells was exacerbated by TOLLIP knockdown, as evidenced by aggravated glomerulus and tubule injury, inflammatory infiltration, and cell apoptosis in the kidney and increased loss of cell viability and apoptotic cells in HK-2 cells. TOLLIP knockdown also enhanced PQ-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation in vivo and in vitro and TLR2/4-NF-κB signaling in vitro, reflected by increased contents of proinflammatory cytokines and expressions of NLRP3 inflammasome-related proteins in the kidney and HK-2 cells and expressions of TLR2, TLR4, and nuclear NF-κB p65 in HK-2 cells. However, TOLLIP overexpression inhibited PQ-induced loss of cell viability, cell apoptosis, NLRP3 inflammasome activation, and TLR2/4-NF-κB signaling in vitro. Additionally, BAY11-7082 abolished TOLLIP knockdown-induced NLRP3 inflammasome activation in vitro, indicating that TOLLIP protected against NLRP3 inflammasome activation in PQ-induced AKI through inhibiting TLR2/4-NF-κB signaling. This study highlights the importance of TOLLIP in AKI after PQ intoxication.

show abstract

Section: Discussionmentioning

confidence: 99%

Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

Zheng

Zhao

Dong

et al. 2021

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…Paraquat (PQ) is a water-soluble agrochemical that is classified as a non-selective herbicide for plantation or defoliation. This herbicide threatens both the environment [1,2] and health [3][4][5]. Biological [6,7], physical [8,9], and chemical treatments [10,11] have all been informed in the previous studies for PQ removal.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Cationic Contaminants by Cyclodextrin Nanosponges Cross-Linked with 1,2,3,4-Butanetetracarboxylic Acid and Poly(vinyl alcohol)

2022

View full text Add to dashboard Cite

Cationic organic pollutants (dyes and pesticides) are mainly hydrosoluble and easily contaminate water and create a serious problem for biotic and abiotic species. The elimination of these dangerous contaminants from water was accomplished by adsorption using cyclodextrin nanosponges. These nanosponges were elaborated by the cross-linking between 1,2,3,4-butanetetracarboxylic acid and β-cyclodextrin in the presence of poly (vinyl alcohol). Their physicochemical characteristics were characterized by gravimetry, acid-base titration, TGA, 13C NMR, ATR-FTIR, Raman, X-ray diffraction, and Stereomicroscopy. The BP5 nanosponges displayed 68.4% yield, 3.31 mmol/g COOH groups, 0.16 mmol/g β-CD content, 54.2% swelling, 97.0% PQ removal, 96.7% SO removal, and 98.3% MG removal for 25 mg/L of initial concentration. The pseudo-second-order model was suitable for kinetics using 180 min of contact time. Langmuir isotherm was suitable for isotherm with the maximum adsorption of 120.5, 92.6, and 64.9 mg/g for paraquat (PQ), safranin (SO), and malachite green (MG) adsorption, respectively. Finally, the reusability performance after five regeneration times reached 94.1%, 91.6%, and 94.6% for PQ, SO, and MG adsorption, respectively.

show abstract

“…Paraquat (PQ) is a water-soluble agrochemical substance used to increase crop yield and safeguard the plants from pests. Nevertheless, this pesticide could menace both health [5][6][7][8] and the environment [9,10]. A concentration of paraquat of 0.1 mg/L has been the maximum permissible concentration for drinking water [11].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Cationic Pollutants from Water by Cotton Rope Coated with Cyclodextrin Polymers

2022

View full text Add to dashboard Cite

The contamination from perilous organic compounds (pesticide and dyes) in water generates a significant problem for the environment and humans. A modified textile was prepared by a coating of anionic cyclodextrin polymer, obtained from the cross-linking between citric acid and β-cyclodextrin in the presence of poly (vinyl alcohol), on the cotton cord for cationic pollutant removal from an aqueous solution. Its physicochemical properties were also characterized by gravimetry, titration, stereomicroscopy, SEM, TGA, 13C NMR, and ATR-FTIR. The CC2 system exhibited 79.2% coating yield, 1.12 mmol/g COOH groups, 91.3% paraquat (PQ) removal, 97.0% methylene blue (MB) removal, and 98.3% crystal violet (CV) removal for 25 mg/L of initial concentration. The kinetics was fitted to the pseudo-second-order model using 6 h of contact time. The isotherm was suitable for the Langmuir isotherm with a maximum adsorption of 26.9 mg/g (PQ), 23.7 mg/g (MB), and 30.3 mg/g (CV). After 120 h of contact time in water and 5% v/v of HCI in ethanol, the weight loss was 7.5% and 5.6%, respectively. Finally, the recyclability performance reached 84.8% (PQ), 95.2% (MB), and 96.9% (CV) after five reuses.

show abstract

Identify the Early Predictor of Mortality in Patients with Acute Paraquat Poisoning

Cited by 16 publications

References 21 publications

Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

Adsorption of Cationic Contaminants by Cyclodextrin Nanosponges Cross-Linked with 1,2,3,4-Butanetetracarboxylic Acid and Poly(vinyl alcohol)

Adsorption of Cationic Pollutants from Water by Cotton Rope Coated with Cyclodextrin Polymers

Contact Info

Product

Resources

About