“…In 12 studies, the risk of bias was judged to be high 19,20,27,28,30,[33][34][35]37,46 or unclear 21,22,36,40,45 , four were at moderate risk of bias 19,20,25,26,41,42,44 and five were at a low risk of bias. 23,24,29,31,39,43 AIMhi 1 was assessed using the qualitative 19 and randomised controlled trial 20 risk-of-bias tools, because these methods were reported separately.…”