Abstract:Sensory receptors, including olfactory receptors (ORs), taste receptors (TAS), and orphan G‐protein coupled receptors (GPRs) have recently been found in a variety of non‐sensory tissues where they have important physiological functions. As G protein‐coupled receptors (GPCRs), these receptors serve as chemosensors by interpreting and responding to chemical cues in their native environment (i.e. blood, urine) and can be activated by naturally occurring metabolites. We reasoned that the liver, the largest metabol… Show more
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