Totally 36 aquifers have been identified along the Mexico-U.S. border. Of these, only 16 have adequate data to provide a reasonable level of confidence to categorize them as transboundary. Limited and/or contrasting data over the other aquifers in the region reflects the void in transboundary groundwater management and assessment mechanisms throughout much of the Mexico-U.S. border. This paper identifies management mechanisms, structures, and institutional prioritization related to transboundary aquifers shared between Mexico and the United States. It also evaluates the differences in the transboundary nature of these aquifers, and how their combined hydrological and geographical considerations interrelate with local and regional social, economic, political, and even scale dimensions to create complex management challenges.