Identifying and Resolving Genome Misassembly Issues Important for Biomarker Discovery in the Protozoan Parasite, Cryptosporidium

Morris, Arthur; Pachebat, Justin A.; Robinson, Guy; Chalmers, Rachel M.; Swain, Martin

doi:10.5220/0007397200900100

Cited by 3 publications

(2 citation statements)

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“…Morris et al have outlined difficulties associated with generating reliable and accurate genome assemblies from clinical isolates of Cryptosporidium (92). They demonstrated that the issues surrounding extracting sufficient DNA from clinical isolates resulted in highly uneven depth of coverage across the genome (for an example, see Figure 3) which can be seen in sequences generated from clinical isolates by a number of research teams.…”

Section: Pitfalls In Genome Assemblymentioning

confidence: 99%

Direct Sequencing of Cryptosporidium in Stool Samples for Public Health

Morris

Robinson

Swain

et al. 2019

Front. Public Health

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Section: Pitfalls In Genome Assemblymentioning

confidence: 99%

Direct Sequencing of Cryptosporidium in Stool Samples for Public Health

Morris

Robinson

Swain

et al. 2019

Front. Public Health

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“…are declared the most widespread diarrheal pathogens worldwide.In developing nations, approximately 20 % of diarrheic children are affected by cryptosporidiosis compared to 1% to 5 % in Europe and North America [5].The developing nations have insufficientdrinking water and sewage disposal networks, so cryptosporidiosis prevalence is higher in rural areas and during the rainy season. HIV/AIDS, Malnutrition, and any immunocompromising disorders considerably upsurge the severity, risk, and prevalence of cryptosporidiosis [6]. The residential surfaces, food, and water contaminated by Cryptosporidium -containing feces serve as infection sources.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Calcium-dependent Protein Kinase 1 from Cryptosporidium parvum: An In-Silico Approach from Protein Modelling to Lead Compounds Identification for Cryptosporidiosis Treatment

2021

IJETER

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A year into the pandemic and there are still so many unknowns. There are very few specific answers about the origin of the virus, but this much is clear. It is not the last pandemic we will face, and far more dangerous pandemics await us in the future.Cryptosporidiosis can produce major epidemics whenever public health measures fails.Human cryptosporidiosis is a diarrheal disease mainly propagated by Cryptosporidium parvum (C. parvum) and Cryptosporidium hominis (C. hominis). It is a self-limited illness in immunocompetent patients but become a severe life-threatening illness in immunocompromised patients and children under five year of age. Several studies have explored the effects of cryptosporidiosis on the mortality rate of younger children. According to one research, about globally 30-50 % death of children of five years occurs due to cryptosporidiosisand is a second primary infection in 12- 13 months toddlers related with fatality. Although many attempts have been made to address this issue,it still lacks effective treatment options. The Nitazoxanide drug has shown moderate efficacy in immunocompetent patients.

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