2019
DOI: 10.3390/ijms20174166
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Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the Xenopus tropicalis Melanocortin-2 Receptor

Abstract: The interaction between the pituitary hormone, adrenocorticotropin (ACTH), and melanocortin-2 receptor (MC2R) orthologs involves the H6 F7 R8 W9 and R/K15 K16 R17 R18 motifs in ACTH making contact with corresponding contact sites on MC2R. Earlier studies have localized the common HFRW binding site of all melanocortin receptors to residues in TM2, TM3, and TM6 that are located close to the extracellular space. The current study has identified residues in Xenopus tropicalis (xt) MC2R in TM4 (I158, F161), in EC2 … Show more

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Cited by 4 publications
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“…Another research article in this Special Issue is by the Dores group [11], who studied activation of the melanocortin-2 receptor. The melanocortin-2 receptor (also known as adrenocorticotropic receptor) is a critical component of the hypothalamic-pituitary-adrenal axis.…”
mentioning
confidence: 99%
“…Another research article in this Special Issue is by the Dores group [11], who studied activation of the melanocortin-2 receptor. The melanocortin-2 receptor (also known as adrenocorticotropic receptor) is a critical component of the hypothalamic-pituitary-adrenal axis.…”
mentioning
confidence: 99%