Identifying pretreatment baseline factors predictive of distant metastasis in patients with nasopharyngeal carcinoma after radiotherapy

Abstract

This retrospective study was performed to identify pretreatment baseline factors that could predict the development of distant metastasis (DM) in patients with nasopharyngeal carcinoma (NPC).A cohort of 119 NPC patients undergoing radiotherapy (RT) or chemoradiotherapy (CRT) were recruited into the study. Among them, 51 developed DM (DM group) within 3 years after treatment and 68 did not (DM-free group). Various clinicopathological factors were measured before the treatment and analyzed by univariate as well as multivariate analyses for the potential correlation with DM development.Univariate analysis revealed that increased peripheral lactate dehydrogenase (LDH) level, lower lymphocyte–monocyte ratio (LMR), higher neutrophil–lymphocyte ratio (NLR), advanced American Joint Committee on Cancer (AJCC) stage, advanced T stage, and advanced N stage were significantly correlated with the presence of DM. Multivariate analysis identified advanced AJCC stage and high LDH level were independent predictive factors for DM.Routinely measured pretreatment clinical factors, including AJCC state and serum LDH level, could independently predict DM. These factors will benefit the selection of appropriate treatment options and improve the overall survival of NPC patients.

Rasio Neutrofil Limfosit, Kesintasan Tiga Tahun Karsinoma Nasofaring Stadium Lokal Lanjut dan Lanjut

“…Sementara itu, Wang, dkk. 6 menemukan bahwa titik potong untuk NLR pada KNF adalah 2,6 dan nilai di atas titik potong tersebut bermakna terhadap kejadian metastasis pada KNF. Hingga saat ini, penelitian tentang nilai titik potong NLR pada berbagai kanker, termasuk KNF belum menemukan titik potong yang seragam.…”

Neutrophil to apolipoprotein A‐I ratio as an independent indicator of locally advanced nasopharyngeal carcinoma

“… 5 Previous studies reported that some routine blood parameters, such as the platelet‐ and neutrophil‐lymphocyte ratio (PLR and NLR, respectively) and red blood cell distribution width (RDW), could be used to evaluate the chronic inflammatory state in each patient and predict survival in those with locally advanced NPC (LA‐NPC). 6 , 7 , 8 , 9 , 10 However, studies on the predictive effect of routine blood biomarkers have reported inconsistent results. For example, increased NLR was shown to be a poor independent risk factor in NPC patients, 6 , 7 while other studies found no significant association of this marker with survival.…”

“…For example, increased NLR was shown to be a poor independent risk factor in NPC patients, 6 , 7 while other studies found no significant association of this marker with survival. 8 , 9 Inflammation and metabolic status indexes (apolipoprotein‐AI [apoA‐I], high‐density lipoprotein‐cholesterol [HDL‐C]) were shown to be protective risk factors in patients with locally advanced stage III to IV NPC patients. 11 , 12 , 13 ApoA‐I is the core apolipoprotein component in HDL‐C, 14 and HDL‐C/apoA‐I exerts anti‐inflammatory and antithrombotic functions by interacting with routine peripheral blood routine indexes (neutrophil, monocyte, lymphocyte, and platelet).…”