1998
DOI: 10.1111/1469-8986.3560621
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Identifying psychophysiological risk for psychopathology: Examples from substance abuse and schizophrenia research

Abstract: A problem confronting the search for psychopathology-related genes concerns the difficulty identifying gene carriers. Psychiatric diagnosis provides imperfect identification of affected individuals, and unaffected gene carriers go undetected. Psychophysiological measures may assist molecular genetic investigations by indicating genetic susceptibility for psychopathology, thus increasing the probability of identifying affected and unaffected gene carriers. Research strategies based on these premises are applied… Show more

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Cited by 101 publications
(4 citation statements)
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“…Three heart electrodes were also placed on the inside of the participants' left inner knee, just above the right collarbone, and on the right side of the neck. A white noise countdown paradigm was presented, modeled after a similar task used in other studies (e.g., Fung et al, 2005;Iacono, 1998). The paradigm consists of four trials; each trial recorded HR and SC patterns during the 3-min baseline period, a 12-s anticipatory period, and a 20-s reactivity period.…”
Section: Hr and Scmentioning
confidence: 99%
“…Three heart electrodes were also placed on the inside of the participants' left inner knee, just above the right collarbone, and on the right side of the neck. A white noise countdown paradigm was presented, modeled after a similar task used in other studies (e.g., Fung et al, 2005;Iacono, 1998). The paradigm consists of four trials; each trial recorded HR and SC patterns during the 3-min baseline period, a 12-s anticipatory period, and a 20-s reactivity period.…”
Section: Hr and Scmentioning
confidence: 99%
“…Given that EDR measures are both heritable and associated with externalizing problems, it is tempting to consider whether hyporeactivity is a marker indexing genetic risk for psychophysiological processes that underlie externalizing psychopathology (Iacono, 1998). According to an information processing account of electrodermal response lability, EDR reflects individual differences in the overt expression of antagonistic impulses (Crider, 2008).…”
Section: Examining Electrodermal Hyporeactivity As a Marker Of Externmentioning
confidence: 99%
“…Frontal θ activity is thought to reflect a reactive mechanism related to successful attentional allocation, orienting, and control-related prefrontal cortex processes ( Başar-Eroglu et al 1992 ; Cavanagh & Frank, 2014 ; Clayton, Yeung, & Kadosh, 2015 ; Harper et al 2017 ), and is a candidate endophenotype for (poly)substance use ( Harper et al 2019b ; Rangaswamy et al 2007 ). Antisaccade performance has been linked to prefrontal inhibitory control ( Hutton & Ettinger, 2006 ), and some evidence suggests it indexes risk for substance use/behavioral disinhibition ( Iacono, 1998 ; Young et al 2009 ). The current findings, if confirmed by future research, suggest that individual differences in a multivariate endophenotype related to frontal executive functioning may index the polygenic risk for both regular smoking and the number of alcoholic drinks per week, which may have significant public health implications given the prevalence of alcohol and nicotine use ( Substance Abuse and Mental Health Services Administration, 2020 ).…”
Section: Discussionmentioning
confidence: 99%