Identifying risk effectors involved in neonatal hypoglycemia occurrence

Zhao, Tian Xin; Liu, Qiying; Zhou, Man; Dai, Wei; Yin, Xinhua; Kuang, Li; Ming, Yaqiong; Sun, Guan

doi:10.1042/bsr20192589

Cited by 14 publications

(8 citation statements)

References 27 publications

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“…There are numerous studies indicating an association between hyperglycemia and/or GDM status and infant hypoglycemia (28,36). Our study observed that higher mean levels of pGCD59, HbA 1c , fasting glucose, 1-hour and 2-hour glucose levels, and GDM status (OGTT < 20 weeks of gestation) were statistically significantly associated with higher rates of NH.…”

Section: Discussionsupporting

confidence: 58%

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The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study

Bogdanet

Luque-Fernandez

Toth-Castillo

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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OBJECTIVE The aim of this study was to assess the association between early pregnancy maternal levels of plasma glycated CD59 (pGCD59) and neonatal hypoglycaemia (NH). MATERIALS and METHODS This is an observational study of pregnant women with a pre-pregnancy body mass index (BMI) ≥ 29 kg/m2 screened for eligibility to participate in the Vitamin D and Lifestyle Intervention for Gestational Diabetes (DALI) trial. This analysis included 399 pregnancies. Levels of pGCD59, were measured in fasting maternal samples taken at the time of a 75 g, 2-hour oral glucose tolerance test (OGTT) performed in early pregnancy (<20 weeks). NH, the study outcome, was defined as a heel-prick capillary glucose level of less than 2.6 mmol/L within 48 h of delivery. RESULTS We identified 30 infants with NH. Maternal levels of pGCD59 in early pregnancy, were positively associated with the prevalence of NH (ANOVA one-way, p-value <0.001). The odds of NH were higher in infants from mothers in the Tertile 3 of pGCD59 levels as compared to those from mothers in Tertile 1 (OR: 2.41, 95% CI: 1.03–5.63). However, this was attenuated when adjusted for maternal BMI (OR: 2.28 (95% CI: 0.96–5.43). The cross-validated area under the curve (AUC) was 0.64 (95% CI: 0.54–0.74), and adjusted for maternal BMI, age, and ethnicity, the AUC was 0.70 (95% CI: 0.56–0.78). CONCLUSION Although pGCD59 levels in early pregnancy in women with BMI ≥29 kg/m2 are associated with NH, our results indicate that this biomarker by itself is only a fair predictor of NH.

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Section: Discussionsupporting

confidence: 58%

“…Zhao et al (28) found that birth weight, poor feeding, and mother's GDM status are statistically significantly associated with NH. Doctor et al (29) found that SGA infants are 5 times more likely to develop hypoglycemia compared to AGA infants.…”

Section: Discussionmentioning

confidence: 99%

The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study

Bogdanet

Luque-Fernandez

Toth-Castillo

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Se encontraron algunas similitudes con los resultados de la investigación de Singh et al donde se encontró como características neonatales más frecuentes: grande para la edad gestacional 25,9 %, sexo masculino 54,7 % (15) . En el estudio realizado por Zhao las características más frecuentes fueron sexo masculino 53,7 %, peso adecuado para la edad gestacional 78 %, recibieron lactancia materna precoz 88,8 % (16) Otras características neonatales como prematuridad, grande para la edad gestacional, otras complicaciones neonatales (RCIU, asfixia, sepsis, policitemia, taquipnea transitoria del recién nacido, síndrome de aspiración meconial) se relacionan con las características maternas, debido a que el neonato depende de la madre para su desarrollo y supervivencia. Un claro ejemplo es el caso del recién nacido grande para la edad gestacional, el cual resulta de altas concentraciones de glucosa materna durante el periodo gestacional, complicando así el trabajo de parto eutócico y favoreciendo algunas repercusiones en el recién nacido durante el parto, como prematuridad, asfixia, taquipnea, sepsis, etc.…”

Section: Discussionunclassified

Hipoglicemia neonatal en recién nacidos a término en un hospital del norte de Perú, 2023

Valencia-Roca,

Becerra-Gutiérrez

2024

Rev Exp Med

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Objective. To determine the frequency and characteristics of hypoglycemia in term newborns attended in a hospital in northern Peru from January to September 2023; Material and methods. Descriptive observational design, quantitative approach. The population consisted of 21 neonates. Results. It was found that the most frequent maternal characteristics were: advanced maternal age (43%), 52% of the mothers had gestational diabetes, the most frequent BMI was obesity (43%), 57% of the mothers had delayed breastfeeding and 57% did not have controlled prenatal checkups. Likewise, 71% had a dystocic delivery. The most frequent neonatal characteristics in the study population were81% male, 43% were large for their gestational age, 62% did not present intrauterine delay, 90% did not present neonatal asphyxia and 76% did not present neonatal sepsis. Of the total number of neonates (1151) admitted to the Hospital Regional Docente de Trujillo during January-September 2023, only 21 (2%) developed neonatal hypoglycemia. Conclusion. It is concluded that among the most frequent maternal characteristics were gestational diabetes, advanced age and poorly controlled pregnant women, and a little more than half had dystocic delivery; and among the most frequent neonatal characteristics were male neonates and large for gestational age newborns. In addition, alow frequency of neonatal hypoglycemia was found in newborns born at term in the regional teaching hospital of Trujillo attended from January to September 2023.

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“…Prolonged neonatal hypoglycemia has been associated with mental retardation, neurological deficits and recurrent seizures. [ 3 ] Some studies have shown perinatal hypoxia, small for gestational age and maternal hypertension to be factors associated with hypoglycemia in preterm newborns [ 4 , 5 ]. However, the exact mechanisms behind the observed negative effects are yet to be identified by neonatologists/endocrinologists to date.…”

Section: Introductionmentioning

confidence: 99%

Asymptomatic hypoglycemia among preterm newborns: A cross-sectional analysis

Salum,

Kalabamu,

Fataki

et al. 2024

PLoS ONE

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Background Hypoglycemia is the commonest metabolic abnormality encountered in newborns. Besides, there is a growing body of evidence that links the causes of early neonatal mortality to neonatal hypoglycemia in Tanzania. However exact factors associated with asymptomatic hypoglycemia in preterm newborns are not known. Objective To assess factors associated with asymptomatic hypoglycemia among preterm newborns. Materials and methods A cross sectional, analytical hospital- based study was carried out at Dar es salaam public regional referral hospitals. Preterm newborns with asymptomatic hypoglycemia were the target population. Data on demographic and clinical characteristics of preterm newborns and their mothers were collected and analyzed using Epi-Info™ software version 7.4. Main data analysis was done by applying a multivariable binary logistic regression model with neonatal random glycaemia coded in a binary fashion at a cut-off point of 2.6 mmol/L. An α-level of 5% was used as a limit of type I error. Results We recruited and analysed 217 preterm newborns within 6–24 hours post-delivery. Male: Female = 1.1:1 (females n = 105, 48.4%). Median glycemic level was 2.6 (IQR; 2.1–3.9) mmol/L. Median gestational age at delivery was 33 (IQR: 30–35) weeks. Breastfeeding within 1st hour post-delivery was a statistically significant factor against glycemic levels associated with hypoglycemia (OR; 0.123, 95%-CI; 0.052–0.287) in a fitted multivariable logistic regression model. Conclusion About half of all preterm newborns studied had glycemic values in a statistical range associated with hypoglycemia. Exclusive breast feeding within 1st hour post-delivery was associated with glycemic levels protective from risk of asymptomatic neonatal hypoglycemia. Recommendations Exclusive breastfeeding practices within 1st hour post-delivery may need to be emphasized to all expectant mothers in order to avoid potential risk of asymptomatic hypoglycemia in preterm newborns.

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Identifying risk effectors involved in neonatal hypoglycemia occurrence

Cited by 14 publications

References 27 publications

The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study

The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study

Hipoglicemia neonatal en recién nacidos a término en un hospital del norte de Perú, 2023

Asymptomatic hypoglycemia among preterm newborns: A cross-sectional analysis

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