Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Schimmel, Samantha; El Sayed, Bassel; Lockard, Gavin; Gordon, Jonah; Young, Isabella; D’Egidio, Francesco; Lee, Jea Young; Rodriguez, Thomas; Borlongan, Cesar V.

doi:10.3390/ijms241914612

Cited by 4 publications

(1 citation statement)

References 129 publications

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“…Increased oxygen levels could promote synaptic plasticity and neurotransmission. Also, there are studies that found benefits related to a reduction in cerebral edema, apoptosis, cerebral glucose utilization, vascular density, and synaptic remodeling, each of which has effects on improved functional and cognitive outcomes ( Schimmel et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of hyperbaric oxygen therapy on autistic behaviors and GRIN2B gene expression in valproic acid-exposed rats

Mohtaj Khorassani,

Moghimi,

Khakzad

et al. 2024

Front. Neurosci.

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IntroductionAutism is a complex neurodevelopmental condition characterized by deficits in social interaction, communication, and restricted repetitive behaviors. Hyperbaric oxygen therapy (HBOT) has emerged as a potential treatment for autism, although its effects on behavior and gene expression are not well understood. The GRIN2B gene, known for its involvement in encoding a glutamate receptor subunit crucial for neuron communication and associated with autism, was a focus of this study.MethodsUsing a rat model induced by prenatal exposure to valproic acid, we examined the impact of HBOT on autism-like behaviors and GRIN2B gene expression. Male Wistar rats were categorized into four groups: control, VPA (valproic acid-exposed), VPA+HBOT [2 atmosphere absolute (ATA)], and VPA+HBOT (2.5 ATA). The rats underwent several behavioral tests to assess social behavior, anxiety, stereotype and exploratory behaviors, and learning. Following the behavioral tests, the HBOT groups received 15 sessions of HBOT at pressures of 2 and 2.5 (ATA), and their behaviors were re-evaluated. Subsequently, real-time PCR was employed to measure GRIN2B gene expression in the frontal lobe.ResultsOur results indicated that HBOT significantly increased social interaction and exploratory behaviors in VPA-exposed rats, alongside elevated GRIN2B gene expression in their frontal lobe.DiscussionOur findings imply that HBOT might have a potential role in ameliorating autism-related behaviors in the VPA rat model of autism through potential modulation of GRIN2B gene expression. However, additional research is essential to fully comprehend the underlying mechanisms and refine the HBOT protocol for optimizing its effectiveness in improving autism-related symptoms.

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Section: Discussionmentioning

confidence: 99%

Effects of hyperbaric oxygen therapy on autistic behaviors and GRIN2B gene expression in valproic acid-exposed rats

Mohtaj Khorassani,

Moghimi,

Khakzad

et al. 2024

Front. Neurosci.

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Hydrogel in the Treatment of Traumatic Brain Injury

Li,

Xu,

Qian

et al. 2024

Biomater Res

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The high prevalence of traumatic brain injury (TBI) poses an important global public health challenge. Current treatment modalities for TBI primarily involve pharmaceutical interventions and surgical procedures; however, the efficacy of these approaches remains limited. In the field of regenerative medicine, hydrogels have garnered significant attention and research efforts. This review provides an overview of the existing landscape and pathological manifestations of TBI, with a specific emphasis on delineating the therapeutic potential of hydrogels incorporated with various bioactive agents for TBI management. Particularly, the review delves into the utilization and efficacy of hydrogels based on extracellular matrix (ECM), stem cell-loaded, drug-loaded, self-assembled peptide structures or conductive in the context of TBI treatment. These applications are shown to yield favorable outcomes such as tissue damage mitigation, anti-inflammatory effects, attenuation of oxidative stress, anti-apoptotic properties, promotion of neurogenesis, and facilitation of angiogenesis. Lastly, a comprehensive analysis of the merits and constraints associated with hydrogel utilization in TBI treatment is presented, aiming to steer and advance future research endeavors in this domain.

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Hyperbaric oxygen for moderate-to-severe traumatic brain injury: outcomes 5–8 years after injury

Zhang,

Li,

et al. 2024

Medical Gas Research

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The use of hyperbaric oxygen (HBO2) in the field of traumatic brain injury (TBI) is becoming more widespread and increasing yearly, however there are few prognostic reports on long-term functional efficacy. The aim of this study was to assess the functional prognosis of patients with moderate-to-severe TBI 5–8 years following HBO2 treatments and to explore the optimal HBO2 regimen associated with prognosis, using a retrospective study. Clinical data were retrospectively collected as a baseline for patients with moderate-to-severe TBI treated with HBO2 during inpatient rehabilitation from January 2014 to December 2017. The primary outcome measure was the Disability Rating Scale (DRS) and the secondary outcome measure was the Glasgow Outcome Scale. A total of 133 patients enrolled, with 9 (6.8%) dying, 41 (30.8%) remaining moderately disabled or worse (DRS scores 4–29), 83 (62.4%) remaining partially/mildly disabled or no disability (DRS scores 0–3). Logistic regression analysis revealed that age at injury (odds ratio (OR), 0.96; 95% confidence interval (CI), 0.92–0.99), length of intensive care unit stay (OR, 0.94; 95% CI, 0.88–0.99), and HBO2 sessions (OR, 0.97; 95% CI, 0.95–0.99) were variables that independently influenced long-term prognosis. Cubic fitting models revealed that 14 and 21.6 sessions of HBO2 could be effective for moderate and severe TBI, respectively. This study highlighted that HBO2 in moderate-to-severe TBI may contribute to minimize death and reduce overall disability in the long-term. However, clinicians should be cautious of the potential risk of adverse long-term prognosis from excessive HBO2 exposure when tailoring individualized HBO2 regimens for patients with moderate-to-severe TBI. The study was registered on ClinicalTrials.gov (NCT05387018) on March 31, 2022.

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Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Cited by 4 publications

References 129 publications

Effects of hyperbaric oxygen therapy on autistic behaviors and GRIN2B gene expression in valproic acid-exposed rats

Effects of hyperbaric oxygen therapy on autistic behaviors and GRIN2B gene expression in valproic acid-exposed rats

Hydrogel in the Treatment of Traumatic Brain Injury

Hyperbaric oxygen for moderate-to-severe traumatic brain injury: outcomes 5–8 years after injury

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