The threat of ontological deflationism (the view that disagreement about what there is can be non-substantive) is averted by appealing to realism about fundamental structure-or so tells us Ted Sider. In this paper, the notion of structural indeterminacy is introduced as a particular case of metaphysical indeterminacy; then it is argued that structural indeterminacy is not only compatible with a metaphysics of fundamental structure, but it can even safeguard it from a crucial objection; finally, it is shown that, if there are instances of structural indeterminacy, a hitherto unacknowledged variety of ontological deflationism will arise. Unless structure is shown to be determinate, ontological deflationism remains a live option. Furthermore, I will consider whether structural indeterminacy could be challenged by adopting a naturalistic epistemology of structure; the question is answered in the negative on the basis of a formal result concerning theory choice. Finally, I submit a new way of articulating the epistemology of structure, which hinges on the very possibility of structural indeterminacy.