Idiopathic central precocious puberty in a Nigerian boy

Ojukwu, Juliana U; Onwe, OE; Modebe, O; Imo, AO; Njeze, M R

doi:10.4314/wajm.v24i1.28171

Cited by 2 publications

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“…The paucity of data in Africa has accounted for low reported incidences in Nigeria. [1] Precocious puberty is divided into two main types A. Gonadotropin-dependent (Central, True, Complete). Here, the cause is traceable to hypothalamic or pituitary pathology B. Gonadotropin-independent precocious puberty (Peripheral and precocious pseudopuberty).…”

Section: Discussionmentioning

confidence: 99%

“…[2] About 90% of cases of central precocious puberty (CPP) are idiopathic in girls and only 10% in boys. [1,3,4] Gonadotropin-independent precocious puberty (Peripheral and precocious pseudopuberty) is mainly due to HCG-secreting tumors, congenital adrenal hyperplasia, tumors of the testis, adrenal or ovary that produce sex steroids, accidental or deliberate exogenous sex steroid administration, hypothyroidism, activating mutations of the LH receptor, and GSα subunit. [5]…”

Section: Discussionmentioning

confidence: 99%

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Precocious puberty in a 30-month-old Nigerian girl: A case report

Eyam¹,

Ekpe²

2018

ijmdcr

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The development of secondary sexual characteristics before the expected age and sex is termed precocious puberty. It is usually due to excessive sex steroids production. Cases of precocious puberty are uncommon worldwide with a prevalence of 1/5000-1/10000 per children population and a female to male ratio of 10:1. In Nigeria, the prevalence is unknown with only a few reported cases, probably due to superstitious and religious beliefs. A high proportion of reported cases globally are of the gonadotropin-dependent (central) type. A case is being reported of a 30-month-old female non-identical twin in Cross River State, South-South of Nigeria, who presented with a 6-month history of bleeding per vagina, premature breast development and pubic hair distribution (Tanner stage 3). The patient had appropriate serum concentrations of the pituitary gonadotrophins and gonadal hormones for age. Precocious puberty was not a finding in the family history, and twin and other siblings had normal growth pattern. Radiological and endocrine investigations were diagnostic of precocious puberty. Hence, being proactive with a high index of suspicion is required of clinicians to be able to identify endocrine abnormalities that are increasing in prevalence and are going unnoticed in our environment, among the pediatric age group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Precocious puberty in a 30-month-old Nigerian girl: A case report

Eyam¹,

Ekpe²

2018

ijmdcr

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“…1,2 The incidence of precocious puberty in Nigeria is not known as there are few reported cases from this part of the world. 3,4 The cause of precocious puberty in girls is unknown in 90% of cases while 8-10% of girls and 25-75% of boys with precocious pu-berty may have structural central nervous system abnormality. 5 Aetiologically, precocious puberty is broadly classified into central and peripheral causes.…”

Section: Introductionmentioning

confidence: 99%

Precocious puberty in a 24 month old Nigerian girl: case report

Oluwayemi¹,

Afolabi²,

Adeniji³

et al. 2020

Nig. J. Paed.

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Precocious puberty refers to the appearance of signs of puberty at an earlier age than is considered normal. It occurs ten times more commonly in girls than in boys. The overall incidence ranged from 1/5000 to 1/10,000 children. The cause is idiopathic in 90% of cases of female precocious puberty. We present BA a 24 month old female toddler who presented with one year history of progressive breast development and 6 month history of pubic hair growth. There was associated increasing weight, height and vaginal secretion. There was no similar occurrence in the family. Mother attained menarche at 14 years of age. Essential finding at presentation revealed a toddler who is heavy and tall for age with a weight of 17kg (>95th percentile for age and sex), height of 90.5cm (90th percentile for age and sex), Occipito-frontal circumference of 49cm (normal). Her sexual maturityrating was Tanner stage 3 for breasts and stage 2 for pubic hair. An assessment of precocious puberty was made. Her investigation result showed an advanced bone age of 5 years; elevated serum gonadotrophins in the pubertal range; and essentially normal cranial CT. Abdomino-pelvic USS showed an enlarged uterus for age, and a dominant right follicle with internal echo measuring 17.1mm X 15.2mm. Parents were counseled on the need for treatment to arrest the progression of precocious puberty but yet to respond because of financial constraint after 2 years of diagnosis. Female precocious puberty is ten times more common than male precocious puberty. The aetiology is idiopathic in 90% of cases and It is amenable to treatment. Integration of the investigation and treatment of childhood endocrine disorders into the National Health Insurance scheme will be a great panacea to the challenge of prompt management in developing countries. Keywords: Precocious, puberty, 24 months old, female, idiopathic, poverty, Nigeria

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Idiopathic central precocious puberty in a Nigerian boy

Cited by 2 publications

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Precocious puberty in a 30-month-old Nigerian girl: A case report

Precocious puberty in a 30-month-old Nigerian girl: A case report

Precocious puberty in a 24 month old Nigerian girl: case report

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