This study aimed to explore the effect of ultrasound imaging in the diagnosis and evaluation of acupoint application in the treatment of idiopathic edema. In this study, an ultrasound imaging diagnosis based on the segmentation dictionary learning (S-DL) algorithm was proposed. In addition, the autoencoding algorithm (ASE) was compared with the traditional dictionary learning (DL) algorithm. The treatment effect, associated quantitative integral, and quality of life score of patients in two groups were compared. The results showed that the peak signal-to-noise ratio (PSNR), root mean square error (RMSE), and structural similarity (SSIM) of the S-DL algorithm were 32.45 dB, 0.654, and 0.0012, respectively, which were quite different compared to the ASE and DL algorithms, showing statistical significance (
P
<
0.05
). As the noise level increased, the image reconstruction quality gradually decreased, but the S-DL algorithm obtained better image quality than the DL and ASE algorithms, and the difference was statistically great (
P
<
0.05
). There was no significant difference in the average age and average course of the disease between the experimental group and the control group (
P
>
0.05
). The overall treatment effect of patients in the experimental group was 96.77%, while that in the control group was 45.16%, and the difference between the two was statistically significant (
P
<
0.05
). After treatment, the semiquantitative scores of fatigue, dizziness, palpitation, frequent urination, urgent urination, and dyspepsia of the experimental group were 1.18, 0.39, 0.72, 1.21, and 0.87, respectively, which were much lower than those of the control group statistically (
P
<
0.05
). The score of quality of life of the experimental group of patients after treatment was 91.27 points, and that of the control group was 82.35 points, showing statistically great difference (
P
<
0.05
). It showed that the algorithm performance of S-DL was relatively good, and the acupoint application therapy was better than traditional western medicine in the treatment of idiopathic edema, which reduces the discomfort of patients to a certain extent and improves the quality of life of patients.