Idiopathic non‐obstructive azoospermia or severe oligozoospermia: a cross‐sectional study in 61 Greek men

Abstract

Idiopathic non-obstructive azoospermia or severe oligozoospermia (INOA) consists a special group of men characterized by eugonadism, primary infertility, low testicular volume, azoospermia or severe oligozoospermia and high follicle stimulating hormone values. Aims of this study were to describe the clinical, hormonal, sperm and histological characteristics of men with INOA and to define if and to what extend men with the INOA phenotype carry Y chromosome long arm (Yq) microdeletions. Sixty-three men with INOA were studied through clinical examination, spermiograms, hormonal profile, polymerase chain reaction for Yq microdeletions, karyotype and testicular fine-needle aspiration biopsy. Sixty-seven men with infertility of known causes and sixty fertile men served as controls. Men with INOA had significantly lower total testosterone levels than fertile men as well as higher prevalence of loss of libido, higher luteinizing hormone levels and lower sperm volume whereas men with infertility of known causes had intermediate values. The prevalence of Yq microdeletions was 3% in men with INOA, 3% in men with infertility of known causes (all of them with abnormal karyotype) and 0% in fertile men. In conclusion, men with INOA have more severe testiculopathy than these with infertility of known causes. These men may be at increased risk of developing partial androgen deficiency of the aging male.

Evaluation of Sperm Chromatin Quality and Screening of Y Chromosome Microdeletions in Greek Males with Severe Oligozoospermia

“…It is therefore indicated that the prevalence of Y microdeletions in the Greek population is probably low. This hypothesis is also supported by the results of a recent study by Giannouli et al [10].…”

Male Sexual Dysfunctions in the Infertile Couple–Recommendations From the European Society of Sexual Medicine (ESSM)

“…There was no difference between the groups of infertile men with semen abnormalities or those with normal semen parameters as compared with the fertile controls. In another case-control study 100 including 61 men with non obstructive azoospermia, 69 with severe oligospermia and 60 fertile men, the authors found the prevalence of LSD (as assessed with a single question) to be 8%, 4%, and 0% respectively.…”

“…Epidemiological studies on LSD among infertile men are limited. Currently, four case-control studies 17 , 20 , 100 , 101 and six observational studies 24 , 26 , 102 , 103 , 104 , 105 have investigated the prevalence of LSD among men from infertile couples ( Table 5 ).…”

“…102 cross-sectional single arm study 514 male patients of infertile couples times out of 10 intercourse without libido (dichotomization not reported) 68.7% —- 4 Giannouli C et al. 100 case-control study 61 men with idiopathic non-obstructive azoospermia vs. with 69 men with known causes of infertility vs. 60 fertile men not provided 8% in idiopathic NOA, 4% in infertile of known cause, 0% in fertile men —- 3 Ramezanzadeh F et al. 103 cross-sectional single arm study 200 men of infertile couples Sexual desire graded in a 5-points Likert scale N/R Longer duration of relationship, of history of infertility, of treatment for infertility and ageing correlated with worse sexual desire greater coitus frequency, mutual understanding within the couple and present sexual satisfaction correlated with better sexual desire 4 Khademi A et al.…”

Λιπιδαιμική Εικόνα Σε Υπογόνιμους Άνδρες Που Λαμβάνουν Αγωγή Με Επιλεκτικούς Ρυθμιστές Των Υποδοχέων Των Οιστρογόνων

“…Οι δοµικές ανωµαλίες των αυτοσωµατικών χρωµοσωµάτων που αποτελούν αιτίες υπογονιµότητας είναι οι µεταθέσεις και οι αµοιβαίες αναστροφές (6,7). (29).…”