Idiopathic thrombocytopenic purpura coexisting with polycythemia vera

Double remission of simultaneously occurring secondary AML and CLL by venetoclax monotherapy

“…Indeed the benefits provided by venetoclax were transitory (just over two months) and were followed shortly by a progression of her AML up to the irreversible evolution of the disease until the patient's death (May 2018). PV and other Ph-MPNs concomitantly associated with other blood-related disorders have been sporadically described [4][5][6], but the simultaneous occurrence of a secondary (AML), diagnosed at the failure of a long-term hypomethylating treatment of a high-risk MDS transformed from a long-lasting Ph-MPN, with a concomitant CLL is extremely rare. Our case posed the traditional therapeutic challenges that daily the practical hematologist encounters in the setting of transformed Ph-MPNs.…”

Resolution of thrombocytopenia, but not polycythemia after ruxolitinib for polycythemia vera with detectable mutation in the exon 12 of the JAK2 gene

“…Of note is that they did not exhibit a significant splenomegaly on physical examination, and ITP diagnosis was established by exclusion of other causes of thrombocytopenia. Moreover, low PLT count increased after steroids introduction [2]. Our PV patient presented with severe thrombocytopenia which was related to two independent mechanisms (1) the presence of autoimmunity and (2) hypersplenism.…”

“…Thrombocytopenia in MF may be due to ineffective megakaryocytopoiesis as a result of bone marrow fibrosis or results from platelet sequestration and destruction in enlarged spleen [1]. Immune dysregulation with the production of immune complexes or antiplatelet antibodies may account for low platelet count in single cases [2]. It is noteworthy that thrombocytopenia remains an exceptional finding in polycythemia vera (PV).…”

Coexistence of immune thrombocytopenic purpura and polycythemia vera

“…There is one source in literature relating to coexistence and treatment of these two diseases [5]. In our article, we have discussed two cases with coexisting PV and ITP and their treatment methods.…”