Idoxuridine—A Preliminary Report

Antiviral PROTACs: Opportunity borne with challenge

“…In addition to antiviral vaccines, nearly a hundred diverse antiviral drugs have been discovered and approved as idoxuridine (IDU) was approved as a first small-molecule inhibitor for the clinical treatment of virus infection ( Ravin et al., 1964 ), human society still faces serious challenges due to newly emerging viruses that lack treatment options and the known viruses with resistance to approved drugs ( Lozano et al., 2012 ). Therefore, extensive efforts have been devoted to the development of antiviral drugs associated with potent efficacy and specific mechanism of action ( Goncalves et al., 2021 ), including covalent inhibitors, immuno-regulators, monoclonal antibodies, host cell killing agents, and others ( De Clercq & Li, 2016 ).…”