If Systems Approach is the Way Forward, What can the Ayurvedic Theory of &lt;i&gt;Tridosha&lt;/i&gt; Teach Us?

Jayasundar, Rama

doi:10.18520/cs/v112/i06/1127-1133

Cited by 10 publications

(8 citation statements)

References 31 publications

(65 reference statements)

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“…Since Ayurveda views disease as a system perturbation (imbalance in vata , pitta and kapha ), a number of factors are considered to play a role in adaptation and hence the Ayurvedic treatment is always multimodal [33], [49]. This also indicates why Ayurvedic medicines are not single molecule-single target as in Western medicine.…”

Section: Discussionmentioning

confidence: 99%

Challenges in integrating component level technology and system level information from Ayurveda: Insights from NMR phytometabolomics and anti-HIV potential of select Ayurvedic medicinal plants

Jayasundar

Ghatak

Makhdoomi

et al. 2019

Journal of Ayurveda and Integrative Medicine

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The work adds onto the list of potential plants for anti-HIV-1 drug molecules. At the same time, it has drawn attention to the different perspectives of Ayurveda and Western medicine underscoring the inherent limitations of conceptual bilinguism between the two systems, especially in the context of medicinal plants. The study has also highlighted the potential of NMR metabolomics in study of plant extracts as used in Ayurveda.

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Section: Discussionmentioning

confidence: 99%

Challenges in integrating component level technology and system level information from Ayurveda: Insights from NMR phytometabolomics and anti-HIV potential of select Ayurvedic medicinal plants

Jayasundar

Ghatak

Makhdoomi

et al. 2019

Journal of Ayurveda and Integrative Medicine

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“…In 2011, a review and theoretical papers appeared in which the term Ayurgenomics was presented [25][26][27][28]. Since 2012, there have been many theoretical and review papers on Ayurgenomics from different angles [29][30][31][32][33][34][35][36][37][38][39][40][41]. In a few of these papers, the focus is also on related fields such as Pharmacogenetics and Ayurnutrigenomics [31,32].…”

Section: Theoretical Papersmentioning

confidence: 99%

“…The development of Ayurgenomics, as we have said, helps give credibility to Ayurveda and other systems of traditional medicine by describing their ancient concepts in terms of modern science. New approaches in Ayurgenomics, which use big data analysis and machine learning, may greatly facilitate this whole process [37,38,40]. Of course, the therapeutic programs of these system will ultimately have to be tested through carefully controlled clinical trials.…”

Section: Modern Medicine and Ayurgenomicsmentioning

confidence: 99%

Ayurgenomics and Modern Medicine

Wallace

2020

Medicina

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Within the disciplines of modern medicine, P4 medicine is emerging as a new field which focuses on the whole patient. The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health. One of the most difficult challenges today is understanding the ancient concepts of Ayurveda in terms of modern science. To date, a number of researchers have attempted this task, of which one of the most successful outcomes is the creation of the new field of Ayurgenomics. Ayurgenomics integrates concepts in Ayurveda, such as Prakriti, with modern genetics research. It correlates the combination of three doshas, Vata, Pitta and Kapha, with the expression of specific genes and physiological characteristics. It also helps to interpret Ayurveda as an ancient science of epigenetics which assesses the current state of the doshas, and uses specific personalized diet and lifestyle recommendations to improve a patient’s health. This review provides a current update of this emerging field.

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“…Ayurveda, on the other hand, understands and addresses disease at the level of organism using system properties. In this sense, Ayurveda is systems biology at a higher level, in comparison to the current cellular-centric approach 57 . A major challenge of systems biology is to differentiate meaningful and functional variations from the neutral ones, comprehend their cumulative effects The universality of coenzyme A implies that it is evolutionary invariant with its identified role and supports the system analysis identifying the Doshas Prakriti of an individual depends on the inheritable properties of encoded proteins and their identifiable alleles in the genome thus making them interrelated.…”

Section: System Approach and Ayurvedamentioning

confidence: 99%

Basis of Disease Manifestation: A Molecular and Ayurvedic Approach with an Integrated Concept of Ayurgenomics

Singh

Gehlot

Agrawal

2019

Journal of Natural Remedies

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Ayurveda and contemporary science comprehends human body as model to understand disease state from very different perspective hence their methodology to describe disease manifestation also seems very different as they observe same problem from different viewpoints. For more precision in healthcare system it is essential that best of both systems need to be integrated, In Ayurvedic texts, the description of concept of basic constitution/Prakriti in health and disease states is well described. The scripts are not clearly understandable and hence its importance has not been properly understood by contemporary biological researchers and thus not utilized. According to Ayurveda individual's basic constitution (Prakriti) influences and directs one's disease status, its treatment & lifestyle regimen. In genomics, individual's basic constitution is decided by its genetic makeup. The current trend in Ayurveda-related biomolecular studies is establishment of high correlation between Prakriti and Genomics. This approach of Ayurgenomics would facilitate the development of alternative methods for cost effective screening of predisposed individuals in the population. This would result in development of an integrated approach to systems biology for disease and health state. For the establishment and success of this concept the prerequisite is integration of Ayurveda into mainstream contemporary biology to achieve global acceptability for the concepts and science of Ayurveda, and for this Ayurvedic concept based phenotypic (Prakriti) assessment needs to be made so that difference among individuals from large population based on their physical, physiological and psychological status can be observed and they can be categorized by their specific predominant Prakriti i.e. Vata, Pitta, Kapha. Information about individual predominant Prakriti can be further analyzed on certain genomic parameters related to gene expression, genetic, epigenetic and biochemical factors, which can be further utilized for Integration of Ayurveda with Genomics for systems biology approach in predictive and personalized medicine.

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If Systems Approach is the Way Forward, What can the Ayurvedic Theory of <i>Tridosha</i> Teach Us?

Cited by 10 publications

References 31 publications

Challenges in integrating component level technology and system level information from Ayurveda: Insights from NMR phytometabolomics and anti-HIV potential of select Ayurvedic medicinal plants

Challenges in integrating component level technology and system level information from Ayurveda: Insights from NMR phytometabolomics and anti-HIV potential of select Ayurvedic medicinal plants

Ayurgenomics and Modern Medicine

Basis of Disease Manifestation: A Molecular and Ayurvedic Approach with an Integrated Concept of Ayurgenomics

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