“…For example, treating these mice with interferon accelerates disease in a T-cell like manner (Z. Liu, et al, 2010;Mathian, et al, 2005), while knocking out or inhibiting interferon-related genes slows or eliminates the development of lupus-like symptoms (Jorgensen, et al, 2007;Sharma, et al, 2005). These mice have been used to clarify the interactions between sex hormones and www.intechopen.com interferon in lupus etiology (Bynote, et al, 2008;Panchanathan, et al, 2009;Panchanathan, et al, 2010), and they serve as an excellent all-around model for spontaneous development of lupus.…”