2006
DOI: 10.1242/jcs.03187
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IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation inCaenorhabditis elegans

Abstract: Defects in cilia are associated with diseases and developmental abnormalities. Proper cilia function is required for sonic hedgehog and PDGFRα signaling in mammals and for insulin-like growth factor (IGF) signaling in Caenorhabditis elegans. However, the role of cilia in these pathways remains unknown. To begin addressing this issue, we are characterizing putative cilia proteins in C. elegans that are predicted to have regulatory rather than structural functions. In this report, we characterized the novel cili… Show more

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Cited by 73 publications
(98 citation statements)
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“…These similarities extend to the components of the BBSome, which actually polymerize a coat in the presence of the Arf-like GTPase ARL6 (also known as BBS3) (Jin et al, 2010). Although there is no experimental evidence that IFT proteins can act as coatomers, the original trafficking function of the IFT system is supported by the finding that two IFT proteins, IFT22 and IFT27, are Rab-like GTPases (Schafer et al, 2006;Qin et al, 2007). Moreover, elipsa (also known as IFT54) has been shown to interact genetically with IFT20 and the Rab5 effector, Rabaptin5 (Omori et al, 2008), with the caveat that the IFT20 interaction with Rabaptin5 was not confirmed in mammalian cells (Follit et al, 2009).…”
Section: Research Articlementioning
confidence: 97%
“…These similarities extend to the components of the BBSome, which actually polymerize a coat in the presence of the Arf-like GTPase ARL6 (also known as BBS3) (Jin et al, 2010). Although there is no experimental evidence that IFT proteins can act as coatomers, the original trafficking function of the IFT system is supported by the finding that two IFT proteins, IFT22 and IFT27, are Rab-like GTPases (Schafer et al, 2006;Qin et al, 2007). Moreover, elipsa (also known as IFT54) has been shown to interact genetically with IFT20 and the Rab5 effector, Rabaptin5 (Omori et al, 2008), with the caveat that the IFT20 interaction with Rabaptin5 was not confirmed in mammalian cells (Follit et al, 2009).…”
Section: Research Articlementioning
confidence: 97%
“…A key signaling pathway regulating C. elegans lifespan and those of other organisms acts via insulin/IGF signaling [15,[32][33][34][35][36][37]. Mutations that prevent the worm from sensing the environment correctly, such as mutants with defective ciliary structures (see below), or compromised sensory signal transduction, exhibit lengthened lifespan via downregulation of insulin signaling [38,39]. Moreover, ablation of specific subsets of chemosensory neurons results in increased or decreased longevity [40], suggesting that different chemosensory neurons promote or antagonize longevity.…”
Section: The Importance Of Chemosensationmentioning
confidence: 99%
“…In Caenorhabditis elegans, ciliary proteins affect life span and dauer formation and therefore implicate cilia in the insulin/insulin-like growth factor 1 (IGF1)-signalling cascades 8,9 . In both mice and humans, primary cilia are found in pancreatic islets on a-, b-and d-cells and in pancreatic ducts, but they are absent from the exocrine portion of the organ [10][11][12] .…”
mentioning
confidence: 99%