This study presents a novel coupled meshless model for simulating acoustic wave propagation in heterogeneous media, based on the singular boundary method (SBM) and Kansa’s method (KS). In the proposed approach, the SBM was used to model the homogeneous part of the propagation domain, while KS was employed to model a heterogeneity. The interface compatibility conditions associated with velocities and pressures were imposed to couple the two methods. The proposed SBM–KS coupled approach combines the respective advantages of the SBM and KS. The SBM is especially suitable for solving external sound field problems, while KS is attractive for nonlinear problems in bounded non-homogeneous media. Moreover, the new methodology completely avoids grid generation and numerical integration compared with the finite element method and boundary element method. Numerical experiments verified the accuracy and effectiveness of the proposed scheme.