IgA Nephropathy Concomitant With Karyomegalic Interstitial Nephritis

Wang, Ziliang; Ni, Xiaona; Zhu, Shuangshuang; Yue, Shuling

doi:10.1016/j.amjms.2020.04.010

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…However, one case of a 15-year-old boy diagnosed with KIN after treatment with ifosfamide and cisplatin showed retardation of kidney disease progression after treatment with a moderate dose of corticosteroids [ 7 ]. Additionally, in a patient with IgA nephropathy and KIN, treatment with methylprednisolone resulted in stabilization of kidney functions [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

et al. 2023

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Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.

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Section: Discussionmentioning

confidence: 99%

Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

et al. 2023

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“…Recently, the first patient with leukemia chemokine for 2 amyloidosis (ALECT2) and KIN, which was caused by a novel deletion in FAN1, was reported [17]. In addition, Wang et al [18] reported for the first time a young man with IgA nephropathy with KIN due to a genetic variant involving the FAN1 gene in exons 14 and 7.…”

Section: Discussionmentioning

confidence: 99%

Heterozygous Variants in a Patient with Karyomegalic Interstitial Nephritis

Wang

Xiao

et al. 2022

Nephron

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Karyomegalic interstitial nephritis (KIN) is a rare kidney disease marked by large tubular nuclei, interstitial inflammation, tubular atrophy, and interstitial fibrosis. The current study presented the case of a 39-year-old man with deteriorating kidney function and a serum creatinine level of 2.08 mg/dL. The renal biopsy revealed that the main pathological features of renal tubular epithelial cells were obvious enlargement, irregular shape, and hyperchromatic nuclei. The genetic analysis of the patient revealed two heterozygous variants in the FAN1 gene, c.2485c>T, and c.2928dupT, located in exons 10 and 13, respectively. A diagnosis of KIN was rendered. The two variations of the proband are identified in separate alleles from the father and mother, respectively, according to his family’s sequencing. This phenotype is consistent with an autosomal recessive pattern of inheritance. The patient was treated with the Chinese patent medicine Niaoduqing Particles. After 38 months of follow-up, renal function was barely changed with a serum creatinine of 1.73 mg/dL.

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