IgA Serological Response for the Diagnosis of Mycobacterium abscessus Infections in Patients with Cystic Fibrosis

Moigne, Vincent Le; Roux, Anne-Laure; Mahoudo, Hélène; Christien, G; Ferroni, Agnès; Dumitrescu, Oana; Lina, Gérard; Bouchara, Jean-Philippe; Plésiat, Patrick; Gaillard, Jean‐Louis; Canaan, Stéphane; Héry-Arnaud, Geneviève; Herrmann, Jean-Louis

doi:10.1128/spectrum.00192-22

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…A recent study has shown the utility of serological testing in the detection of culture-positive cases of M. abscessus infection in CF patients [ 90 ]. The test was based on the detection of IgA against M. abscessus protein, recombinant PLC (rPLC), and the TLR2eF extract.…”

Section: Introductionmentioning

confidence: 99%

“…The test was based on the detection of IgA against M. abscessus protein, recombinant PLC (rPLC), and the TLR2eF extract. This IgA ELISA was able to differentiate M. abscessus from M. avium and M. chimaera infections (but not from M. intracellulare infection) based on the recognition of MABC proteins or extracts, in contrast to the older test which is based on the detection of antibodies recognizing the GPL core antigen of M. avium [ 90 ]. The prevalence of NTM infection in CF patients is currently being tested in a prospective study (clinical study number ID RCB:2017-A00025-48) using both ELISAs.…”

Section: Introductionmentioning

confidence: 99%

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The roles of neutrophils in non-tuberculous mycobacterial pulmonary disease

Alkarni

Lipman

Lowe

2023

Ann Clin Microbiol Antimicrob

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Non-tuberculous Mycobacterial Pulmonary Disease (NTM-PD) is an increasingly recognised global health issue. Studies have suggested that neutrophils may play an important role in controlling NTM infection and contribute to protective immune responses within the early phase of infection. However, these cells are also adversely associated with disease progression and exacerbation and can contribute to pathology, for example in the development of bronchiectasis. In this review, we discuss the key findings and latest evidence regarding the diverse functions of neutrophils in NTM infection. First, we focus on studies that implicate neutrophils in the early response to NTM infection and the evidence reporting neutrophils’ capability to kill NTM. Next, we present an overview of the positive and negative effects that characterise the bidirectional relationship between neutrophils and adaptive immunity. We consider the pathological role of neutrophils in driving the clinical phenotype of NTM-PD including bronchiectasis. Finally, we highlight the current promising treatments in development targeting neutrophils in airways diseases. Clearly, more insights on the roles of neutrophils in NTM-PD are needed in order to inform both preventative strategies and host-directed therapy for these important infections.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The roles of neutrophils in non-tuberculous mycobacterial pulmonary disease

Alkarni

Lipman

Lowe

2023

Ann Clin Microbiol Antimicrob

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“…Serological diagnostic approaches including IgG-and IgAbased ELISA assays have been evaluated for MAC and MABS infection and show early promise. [61][62][63][64][65] Prospective studies involving larger pediatric and adult populations in a range of clinical settings are required to confirm the utility of these tests to aid NTM diagnosis in pwCF.…”

Section: Diagnosis Detection and Screeningmentioning

confidence: 99%

Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators

Burke

Thomson

Wainwright

et al. 2023

Semin Respir Crit Care Med

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Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, though recent work has suggested clustered clonal infections do occur and transmission potential demonstrated among pwCF attending CF specialist centers. Guidelines for the screening, diagnosis, and identification of NTM and management of pwCF have been published. The emergence of CF-specific therapies, in particular cystic fibrosis transmembrane regulator (CFTR) modulator drugs, have led to significant improvement in the health and well-being of pwCF and may lead to challenges in sampling the lower respiratory tract including to screen for NTM. This review highlights the epidemiology, modes of acquisition, screening and diagnosis, therapeutic approaches in the context of improved clinical status for pwCF, and the clinical application of CFTR modulator therapies.

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Cystic Fibrosis-Related Nontuberculous Mycobacterial Pulmonary Disease

Baird,

Bell

2023

Clinics in Chest Medicine

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IgA Serological Response for the Diagnosis of Mycobacterium abscessus Infections in Patients with Cystic Fibrosis

Cited by 4 publications

References 23 publications

The roles of neutrophils in non-tuberculous mycobacterial pulmonary disease

The roles of neutrophils in non-tuberculous mycobacterial pulmonary disease

Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators

Cystic Fibrosis-Related Nontuberculous Mycobacterial Pulmonary Disease

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