IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis

Mizerska-Wasiak, Małgorzata; Winiarska, Maria; Nogal, Karolina; Cichoń-Kawa, Karolina; Pańczyk-Tomaszewska, Małgorzata; Małdyk, Jadwiga

doi:10.3390/pediatric13030048

Cited by 6 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Latent viral infection reactivation has been considered in the setting of immunosuppression. CMV complicating HSP was observed in both children and adults after high-dose steroid therapy [ 53 , 54 ].…”

Section: Environment Microbial and Virus Infectionsmentioning

confidence: 99%

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Nikolaishvili

Pazhava

Lernia

2023

JCM

View full text Add to dashboard Cite

Henoch–Schönlein purpura or IgA vasculitis is the most common type of pediatric vasculitis that may affect adults as well. It is classified as a type of small-vessel vasculitis. It can cause cutaneous and systemic symptoms with a minority of patients developing kidney failure. Little is known about the specific pathophysiology of this disorder, except that it is believed to occur in individuals with abnormally glycosylated IgA1. Serum aberrant IgA1 may form large antigen–antibody complexes which, due to a defective clearance, are able to deposit in the small vessels of the skin, kidney, gut, and joints. A variety of factors, including infectious agents, drugs, and vaccines, have been identified as potential triggers. The majority of cases are preceded by upper respiratory tract infections, and seasonal variations suggest a link with many pathogens. The etiologic agent most frequently associated with IgA vasculitis historically have been group A β-hemolytic streptococcus and common respiratory tract viruses. However, during the current coronavirus pandemic, SARS-CoV-2 infection was identified as a main trigger factor. In addition, IgA vasculitis has been observed following COVID-19 immunization. This review provides insights into the state of the art on the relationship between viral infections, viral vaccines, and Henoch–Schönlein purpura.

show abstract

Section: Environment Microbial and Virus Infectionsmentioning

confidence: 99%

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Nikolaishvili

Pazhava

Lernia

2023

JCM

View full text Add to dashboard Cite

show abstract

“…Hu et al [ 46 ] also reported that EBV can trigger HSP via cellular and humoral immunity. Several cases of HSP with CMV have suggested that CMV may be a contributing factor [ 47 , 48 , 49 ]. Shin et al [ 50 ] have reported that hepatitis B surface antigens play a role in HSP development.…”

Section: Discussionmentioning

confidence: 99%

An Investigation of the Relationship between Henoch-Schönlein Purpura and Viral Infection in Korea Using the Health Insurance Database

Park,

Jo,

Kim

et al. 2024

JCM

View full text Add to dashboard Cite

(1) Background: This study investigated the epidemiology and viral connections of Henoch–Schönlein purpura (HSP) using information from the Korea Disease Control and Prevention Agency and the Health Insurance Review and Assessment database. (2) Method: Between 2016 and 2019, a total of 25,443 patients with HSP were identified, with 51.3% of patients under the age of 20 years and the highest incidence in March. (3) Results: The autoregressive integrated moving average model and Granger causality test were used to analyze the association between the virus positivity detection rate and HSP incidence. (4) Conclusions: The incidence of HSP was associated with rotavirus, bocavirus, parainfluenza virus, and respiratory syncytial virus in individuals under 20 years of age, whereas adenovirus, respiratory syncytial virus, and norovirus were associated with individuals above that age.

show abstract

“…As native IgAN is considered to be closely related to the pathogenesis of mucosal immunity, such as upper respiratory tract infection and intestinal infection [20], preceding infections might contribute to the onset or exacerbation of posttransplantation recurrent IgAN. Thus, there are several studies that reported IgAN or IgA vasculitis accompanied by CMV infection [21–23], yet the relationships between C1q deposition and infections have not been addressed in those studies. In our study, patients with peripheral C1q deposition in the Recurrent group had a higher incidence of endocapillary hypercellularity.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Significance of Mesangial C1q Deposition in Kidney Transplant Recipients with Recurrent IgA Nephropathy and Patients with Native IgA Nephropathy

Hayashi

Kawabe

Yamamoto

et al. 2023

Nephron

View full text Add to dashboard Cite

Introduction: In kidney transplant recipients (KTRs) whose primary disease is IgA nephropathy (IgAN), IgAN recurrence occurs in approximately half of patients by 5 years postoperatively and is associated with graft survival. Although the alternative and lectin pathways are important in the primary pathogenesis of IgAN, the significance of mesangial C1q deposition, which triggers the classical pathway, is unknown. We investigated the clinicopathological significance of mesangial C1q deposition in both recurrent IgAN in KTRs and native IgAN. Methods: Between 2000 and 2021, we conducted a 1:2 matched case-control study of 18 KTRs diagnosed with recurrent IgAN, with a group of native IgAN patients as the control. We evaluated the rate and presence/absence of mesangial C1q deposition in terms of pathological findings and kidney outcomes in each group. Results: The rate of mesangial C1q deposition was significantly higher in the recurrent IgAN patients in KTRs than in native IgAN patients (11/18 [61.1%] vs. 5/36 [13.9%], p = 0.001). In the former group, the incidence of glomerular crescents was relatively higher in C1q-positive patients. There was no significant difference in the annual rate of estimated glomerular filtration rate decline between C1q-positive and C1q-negative patients in either group. Conclusion: Mesangial C1q deposition was more frequent in KTRs with recurrent IgAN than in patients with native IgAN, but we found no difference in kidney outcomes with respect to mesangial C1q deposition. Further large-scale investigations of the importance of mesangial C1q deposition are needed in both KTRs with recurrent IgAN and patients with native IgAN.

show abstract

IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis

Cited by 6 publications

References 14 publications

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Viral Infections May Be Associated with Henoch–Schönlein Purpura

An Investigation of the Relationship between Henoch-Schönlein Purpura and Viral Infection in Korea Using the Health Insurance Database

Clinical and Pathological Significance of Mesangial C1q Deposition in Kidney Transplant Recipients with Recurrent IgA Nephropathy and Patients with Native IgA Nephropathy

Contact Info

Product

Resources

About