IgA vasculitis nephritis

Nüsken, Eva; Weber, Lutz T.

doi:10.1097/mop.0000000000001120

Cited by 9 publications

(6 citation statements)

References 71 publications

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“…IgA nephropathy (IgAN) and the histologically related IgA vasculitis nephritis (IgAVN, formerly Henoch-Schönlein purpura (HSP) nephritis) are collectively the most common causes of glomerulonephritis worldwide and a frequent cause of glomerulonephritis in children [ 39 ]. In Europe, IgAN is detected in 20% of children with glomerular diseases diagnosed by kidney biopsy [ 40 ].…”

Section: Some Selected Causes Of Glomerular Hematuriamentioning

confidence: 99%

“…IgAV is the most common vasculitis in children [ 39 , 40 ]. Typical clinical symptoms include palpable purpura (without thrombocytopenia and coagulopathy), arthritis or arthralgia, and abdominal pain.…”

Section: Some Selected Causes Of Glomerular Hematuriamentioning

confidence: 99%

“…Nephritis (IgAVN) occurs in about 30% of patients with IgAV. The extent of kidney damage is the most significant prognostic element in determining morbidity and mortality [ 39 , 40 ].…”

Section: Some Selected Causes Of Glomerular Hematuriamentioning

confidence: 99%

“…Their pathogenesis is complex and several different pathways are likely to be involved, interacting in a complex network [41] assuming the role of a common, in most cases unidentified, infectious trigger [40,41]. IgAV is the most common vasculitis in children [39,40]. Typical clinical symptoms include palpable purpura (without thrombocytopenia and coagulopathy), arthritis or arthralgia, and abdominal pain.…”

Section: Immunoglobulin a Nephropathymentioning

confidence: 99%

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How to define and assess the clinically significant causes of hematuria in childhood

2022

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Given the wide diversity of causes of hematuria, ranging from simple urinary tract infections with rapid recovery to severe glomerulonephritis with fast decline in kidney function, it is essential to recognize the underlying disease. The first objective of the assessment is to determine whether the cause of the hematuria is medically significant. The combination of hematuria with proteinuria, the presence of hypertension, or worsening kidney function can represent signs of progressive kidney disease. Differentiating the various causes of hematuria is often simple and obvious based on the clinical signs and gross appearance of the urine. However, in some instances, additional non-invasive investigations, such as ultrasound imaging, urinary red cell morphology, measurement of calcium and other solutes in the urine, evaluation of kidney function, and protein excretion, are needed to elucidate the nature of the hematuria. Taking a detailed family history can help in establishing the underlying cause in cases of familial hematuria. On the other hand, the decision to perform a kidney biopsy in children with asymptomatic hematuria remains a challenging issue for clinicians. Ultimately, the frequency of diagnosis of glomerular involvement causing hematuria may depend on the threshold for performing a kidney biopsy. The following review will focus on the diagnostics of hematuria, starting with difficulties regarding its definition, followed by various means to differentiate between urinary, glomerular, and other causes, and finally reviewing the most common diseases that, due to their frequency or their effect on kidney function, present a diagnostic challenge in everyday practice.

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Section: Some Selected Causes Of Glomerular Hematuriamentioning

confidence: 99%

Section: Some Selected Causes Of Glomerular Hematuriamentioning

confidence: 99%

“…Nephritis (IgAVN) occurs in about 30% of patients with IgAV. The extent of kidney damage is the most significant prognostic element in determining morbidity and mortality [ 39 , 40 ].…”

Section: Some Selected Causes Of Glomerular Hematuriamentioning

confidence: 99%

Section: Immunoglobulin a Nephropathymentioning

confidence: 99%

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How to define and assess the clinically significant causes of hematuria in childhood

2022

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“…The incidence of kidney pathologies, nephrosis and nephritis in particular, is constantly growing all over the world in recent years [1][2][3]. The number of patients with acute IAI associated with nephritis is constantly growing [4] respectively.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

JUNS

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Introduction: Actuality is due to rather understudied state of fibrinolytic reactions in case of NN with acute IAI which is to be found in practice more frequent. Objective of the study was studying of the features of fibrinolytic activity in case of IAI, that is being developed underlying NN.Materials and Methods: 100 albino non-pedigree rats. IAI was simulated through the intra-abdominal puncture injection of a 20% auto fecal mixture. NN was simulated by subcutaneous introduction of 5% sodium nitrite solution on distilled water. In the course of the study total TFA, NFA and EFA of blood plasma were studied. The animals were divided into such groups: 1 -intact animals with IAI models, 2 -animals with models of IAI underlying NN. Results:The activity of fibrinolysis in animals with NN models predominated over the one in intact animals. In 6 hours since IAI was modeled, FA started increasing in both animal groups. However, all of TFA, EFA and NFA in group 1 were increasing statistically significantly. Whereas group 2 was affected by a minor increase. In 12 hours in group 1 FA of plasma was increasing statistically significantly. In group 2 FA of plasma was increasing insignificantly. There was a meaningful increase of EFA in group 1, in contrast, it was insignificant in group 2. The ratio between EFA and NFA decreased in group 1. In contrast, this ratio in group 2 increased statistically significantly and the parameters of EFA indicator in group 2 were statistically significantly higher. In 24 hours, parameters of TFA, NFA and EFA indica-tors in both groups have not changed much. At the same time, the ratio between EFA and NFA was increasing statistically significantly in group 1. In group 2 the ratio decreased. In 48 hours, FA plasma and the ratio of different fibrinolysis elements did not change much in group 1. The parameters of TFA and EFA in group 2 were increasing statistically significantly. The parameters of NFA were decreasing statistically significantly. The ratio between EFA and NFA in group 2 was decreasing very significantly. Conclusiona) The increase in the fibrinolytic activity of blood plasma with the non-enzymatic mechanism's predomination have been found in experimental nephrosis-nephritis case.b) The activation of fibrinolysis with balance maintenance between its links within 24 hours has been observed in experimental acute intra-abdominal infection case. c) In 6 hours, the development of acute intra-abdominal infection in animals with simulated nephrosis-nephritis differs substantially in its quantitative characteristics of the fibrinolytic activity of plasma blood, which is shown by its lack of proper increase, development of imbalance be-tween the links of fibrinolysis, uncontrolled increase of the activity of fermentation mechanisms with disseminated intravascular coagulation syndrome in 48 hours.d) The basis of the differences that have been detected are the changes in the functional activity of the fibrinolytic system caused by nephrosis-nephritis influence that, in addition to changes in ...

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