IgE‐associated allergic disorders: recent advances in etiology, diagnosis, and treatment

Zellweger, Fabian; Eggel, Alexander

doi:10.1111/all.13059

Cited by 35 publications

(34 citation statements)

References 90 publications

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“…IgE is secreted by B cells that are stimulated by inhaled allergens; allergen-IgE cross-linking then triggers allergic inflammatory responses (1,33). Thus, a high IgE level is considered a risk factor for allergen-related symptoms, and it has been experimentally observed in several studies of allergic diseases (6,15,34,35). Recently, Cahenzli et al found that a gut microbiota with a low level of diversity would lead to increased IgE levels, which cause systemic anaphylaxis; however, a highly diverse gut microbiota does not lead to hyper-IgE (36).…”

Section: Discussionmentioning

confidence: 99%

Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis

et al. 2018

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Abnormalities in the human microbiota are associated with the etiology of allergic diseases. Although disease site-specific microbiota may be associated with disease pathophysiology, the role of the nasal microbiota is unclear. We sought to characterize the microbiota of the site of allergic rhinitis, the inferior turbinate, in subjects with allergic rhinitis ( = 20) and healthy controls ( = 12) and to examine the relationship of mucosal microbiota with disease occurrence, sensitized allergen number, and allergen-specific and total IgE levels. Microbial dysbiosis correlated significantly with total IgE levels representing combined allergic responses but not with disease occurrence, the number of sensitized allergens, or house dust mite allergen-specific IgE levels. Compared to the populations in individuals with low total IgE levels (group IgE), low microbial biodiversity with a high relative abundance of phylum () and a low relative abundance of phylum () was observed in individuals with high total serum IgE levels (group IgE). Phylogeny-based microbial functional potential predicted by the 16S rRNA gene indicated an increase in signal transduction-related genes and a decrease in energy metabolism-related genes in group IgE as shown in the microbial features with atopic and/or inflammatory diseases. Thus, dysbiosis of the inferior turbinate mucosa microbiota, particularly an increase in and a decrease in, is linked to high total IgE levels in allergic rhinitis, suggesting that inferior turbinate microbiota may be affected by accumulated allergic responses against sensitized allergens and that site-specific microbial alterations play a potential role in disease pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis

et al. 2018

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“…They involve a sensitization process including drug-induced activation of Th2 cells, producing specific IgE (sIgE). 137 These sIgEs bind to the FcεRI receptor on mast cells and basophils. In subsequent drug contacts, the simultaneous recognition by at least two sIgE initiates the degranulation and release of mediators.…”

Section: Ige-mediated Reactionsmentioning

confidence: 99%

Recent developments and highlights in drug hypersensitivity

Mayorga

Fernandez

Montañez

et al. 2019

Allergy

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Drug hypersensitivity reactions (DHRs) are nowadays the third cause of allergy after rhinitis and asthma with a significant increase in prevalence in both adults and paediatric population with new drugs included as culprit. For this, DHRs represent not only a health problem but also a significant financial burden for affected individuals and health systems. Mislabelling DHRs is showing to be a relevant problem for both, false label of drug allergic and false label of nonallergic. All this reinforces the need to improve accurate diagnostic approaches that allow an appropriate management.Moreover, there is a need for training both, nonallergist stakeholders and patients to improve the reaction identification and therefore decrease the mislabelling. The use of allergy cards has shown to be relevant to avoid the induction of DHRs due to the prescription of wrong medication.Recent developments over the last 2 years and highlights about risk factors, diagnostic approaches, mechanisms involved as well as prevention actions, and management have been reviewed. In these papers, it has been outlined the need for correct diagnosis and de-labelling of patients previously false-reported as allergic, which will improve the management and treatment of patients with DHRs. K E Y W O R D Sallergy diagnosis, allergy treatment, basic mechanisms, drug allergy, epidemiology | 2369

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“…Allergic diseases are complex and represent multiple phenotypes such as clinically silent IgE sensitization, isolated phenotypes such as only rhinitis, asthma, dermatitis, food allergy and multimorbidities associating several conditions in the same subject.…”

Section: Introductionmentioning

confidence: 99%

The asthma‐rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults

Siroux

Ballardini

Solèr

et al. 2018

Allergy

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IgE‐associated allergic disorders: recent advances in etiology, diagnosis, and treatment

Cited by 35 publications

References 90 publications

Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis

Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis

Recent developments and highlights in drug hypersensitivity

The asthma‐rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults

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