IgE-CONTAINING PLASMA CELLS IN ACUTE TUBULO-INTERSTITIAL NEPHROPATHY

Faarup, Poul; Christensen, Erik

doi:10.1016/s0140-6736(74)93292-9

Cited by 23 publications

(7 citation statements)

References 3 publications

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“…nephritis probably induced by drug therapy. It would be also in agreement with the finding, reported by Faarup and Christensen [14], that IgEcontaining plasma cells are present in perivascular infiltrates found in renal specimens during barbiturate-induced tubulointerstitial nephropathy.…”

Section: Discussionsupporting

confidence: 93%

Acute Renal Failure After Rifampicin: a Case Report and Survey of the Literature

Nessi¹,

Bonoldi²,

Redaelli³

et al. 1976

Nephron

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A new case of acute renal failure after rifampicin is presented, together with a review of the 36 similar cases published up to date in the literature. Evidence is provided that irregularities in drug intake, either as true intermittent treatment or as discontinuation of continuous therapy, play an important role in the pathogenesis of such reactions. Renal failure appeared after a rather long uneventful interval from the beginning of rifampicin therapy, ranging from 1 month to more than 1 year. Its clinical course was favourable in all but one case; the histological picture was mainly of tubulo-interstitial type. The controversial immunological data reported in the literature are reviewed; an increase of histamine release by rat mast cells has been found in presence of rifampicin plus the serum of our patient: the implications of this finding are discussed, suggesting a possible immunological factor in the pathogenesis of acute renal failure after rifampicin.

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Section: Discussionsupporting

confidence: 93%

Acute Renal Failure After Rifampicin: a Case Report and Survey of the Literature

Nessi¹,

Bonoldi²,

Redaelli³

et al. 1976

Nephron

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“…The onset mechanisms of DIAN have been thought to associate multifactoricallv with the hypersensitive reac tions of types I-IV [9][10][11][12][13], However, the mechanisms of cellular immunity have certain benefits to account for the pathophysiology of DIAN in terms of the clinical aspects, which is supported by the positive data of LST. An animal model has been suggested in which immu nized bovine gamma-globulin is injected into the kidney of a rat to induce AIN.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characterization of Drug-Induced Allergic Nephritis

Shibasaki

Ishimoto²,

Sakai³

et al. 1991

Am J Nephrol

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To elucidate the clinical characterization of drug-induced allergic nephritis (DIAN), we analyzed the cases attending our department. We now report on the 14 cases of DIAN due to administration of penicillin in 2 cases, cephem antibiotics in 6 cases, nonsteroidal anti-inflammatory drugs in 4 cases and new quinolone anticidal drugs in 2 cases. With 1 exception, all these cases reached the stage of acute renal failure after taking these drugs for 2–13 days, followed by characteristic allergic symptoms such as fever, skin eruptions and serum IgE elevation in 5 of the 14 cases. A lymphocyte stimulation test (LST) with the suspected drugs proved to be positive in 10 of the 12 cases examined, and the uptake of ⁶⁷Ga in the kidneys was extremely positive in all 6 cases examined, reflecting the natural course of this disease. Furthermore, there were some cases where ⁶⁷Ga accumulated in the kidneys in spite of the negative result of LST examination. In all of these cases, a needle or open renal biospy was performed, and acute tubulointerstitial nephritis (AIN) was diagnosed. Almost all cases were treated with glucocorticoid for AIN or dialysis for acute uremic symptoms several times. However, 4 of the 14 cases could not return to normal condition in spite of these forms of treatment. We would therefore like to suggest that LST and ⁶⁷Ga scintigram are useful diagnostic tools for DIAN as an alternative to renal biopsy.

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“…The presence of linear deposits of IgG along the TBM, indicative of anti-TBM antibodies, is the exception rather than the rule [49,91,118]. In one individual, plasma cells containing IgE were identified in the kidney interstitium [45]. In another patient, granular immune deposits containing IgE were seen along the TBM [68].…”

Section: Lesions Mediated By Immediate Type Hypersensitivitymentioning

confidence: 99%