IgE-Mediated Anaphylaxis Induced by Macrogol 6000

Caballero, María Luisa; Lluch-Bernal, M; Vilà-Nadal, Gemma; Lluncor, Marina; Quirce, Santiago

doi:10.18176/jiaci.0089

Cited by 15 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We then performed dot-blot IgE-immunodetection, which yielded negative results. No specific IgE binding to the material analyzed was detected [2], although specific IgE to other pharmaceutical excipients has been reported using this technique [3].…”

mentioning

confidence: 85%

“…Administration of dupilumab improves the signs and symptoms of AD, including pruritus and anxiety and depression, and enhances patient quality of life [2,3]. A reassuring safety profile has been established, with conjunctivitis being the most significant safety signal [2][3][4]. We describe a patient with severe AD treated with dupilumab who developed alopecia areata within 6 weeks of his first exposure.…”

Section: Fundingmentioning

confidence: 98%

“…Dupilumab is the first biological therapy to be approved for treatment of moderate-to-severe AD in adults who are candidates for systemic therapy. Administration of dupilumab improves the signs and symptoms of AD, including pruritus and anxiety and depression, and enhances patient quality of life [2,3]. A reassuring safety profile has been established, with conjunctivitis being the most significant safety signal [2][3][4].…”

Section: Fundingmentioning

confidence: 99%

See 2 more Smart Citations

Anaphylaxis Due to Poloxamer 238

Carbonell

Escudero

Miralles

et al. 2018

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

mentioning

confidence: 85%

Section: Fundingmentioning

confidence: 98%

Section: Fundingmentioning

confidence: 99%

See 1 more Smart Citation

Anaphylaxis Due to Poloxamer 238

Carbonell

Escudero

Miralles

et al. 2018

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

“…Of the 17 case reports found, six were due to an adverse effect to a surfactant [12][13][14][15][16][17]. These include an 80-year-old female patient who developed an injection site reaction due to polysorbates in PCSK9i formulations [14].…”

Section: Plos Onementioning

confidence: 99%

Biologic excipients: Importance of clinical awareness of inactive ingredients

Ionova

Wilson

2020

PLoS ONE

View full text Add to dashboard Cite

Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added to increase product stability, maintain tonicity, and facilitate drug delivery. The potential implications of these additive substances merit clinical consideration. We assessed the safety risk of excipients on the basis of their type and variability through an assessment framework, which quantifies excipient complexity in 230 biological formulations, and identifies excipient-related adverse events through published case reports. A biologic on average contained 4.45 excipients, half of that found in oral medications. The frequency distribution was heavily skewed towards the most commonly occurring excipients: water (40.4%), sodium chloride (38.3%), polysorbate 80 (28.7%), sucrose (24.4%), and mannitol (20.9%), with 44.4% of formulations not listing the concentration of the most commonly occurring inactive ingredients. A literature search revealed only 17 case reports of excipient-related adverse events, suggesting the need for more clarity for clinicians on the safety of chemical additives. These cases included injection site reactions, anaphylaxis, hyperglycemia, and acute renal failure. With the expansion of the biopharmaceutical market, it is important to consider the safety data of biologic excipients, so that therapy can be tailored appropriately for a specific patient.

show abstract

“…Although macrogol is generally considered biologically inert, the incidence of hypersensitivity to this agent has recently increased in adults [1]. Furthermore, a case of IgE-mediated anaphylaxis induced by macrogol has been reported [6]. However, awareness of the allergic potential of macrogol remains poor among medical professionals [1], of whom very few suspect macrogol as the causative agent in immediate hypersensitivity reactions, particularly in children.…”

Section: Recurrent Immediate Type Hypersensitivity Reaction Induced Bmentioning

confidence: 99%