IgE‐mediated anaphylaxis to proton pump inhibitors – cross‐reacting study

Vovolis, V.; Koutsostathis, Nikolaos; Stefanaki, E.

doi:10.1111/j.1398-9995.2008.01796.x

Cited by 23 publications

(13 citation statements)

References 6 publications

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“…The specificity and positive predictive value of our skin tests were both 100%, whereas the sensitivity and negative predictive value were 58.8% and 70.8%, respectively. There have been several reports of hypersensitivity reactions to PPIs , most being case reports with few patients. One large study has compared the diagnostic performance of skin tests vs OPTs in 53 patients with immediate reactions to PPIs.…”

Section: Discussionmentioning

confidence: 99%

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Immediate-type hypersensitivity reactions to proton pump inhibitors: usefulness of skin tests in the diagnosis and assessment of cross-reactivity

Özdemir

Yılmaz²,

Aydın³

et al. 2013

Allergy

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Section: Discussionmentioning

confidence: 99%

“…Although hypersensitivity reactions due to PPIs are rare, several anaphylactic reactions have been reported . However, limited data are available about the value of skin tests in the diagnosis of PPI‐induced hypersensitivity reactions and the cross‐reactivity between PPIs .…”

mentioning

confidence: 99%

Immediate-type hypersensitivity reactions to proton pump inhibitors: usefulness of skin tests in the diagnosis and assessment of cross-reactivity

Özdemir

Yılmaz²,

Aydın³

et al. 2013

Allergy

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“…Although hypersensitivity reactions due to PPIs are rare, several anaphylactic reactions have been reported [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. The frequency of life-threatening reactions due to immediate hypersensitivity to PPIs and the common usage of these drugs make PPI hypersensitivity a significant problem.…”

Section: Introductionmentioning

confidence: 99%

Management of Hypersensitivity Reactions to Proton Pump Inhibitors: A Retrospective Experience

Özdemir

Erkekol²,

Ünal³

et al. 2016

Int Arch Allergy Immunol

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Background: We previously reported perfect specificity and low sensitivity of skin tests in proton pump inhibitor (PPI)-induced immediate hypersensitivity reactions in a prospective multicenter study. Here, in a retrospective study, we aimed to further evaluate the diagnostic workup procedures and characteristics of the patients with suspected PPI hypersensitivity. Methods: This national multicenter study was conducted as a retrospective chart review of patients with a history of PPI-induced immediate hypersensitivity reaction. A total of 60 patients were included. Results of diagnostic workup procedures (standardized skin-prick, intradermal, and oral-provocation tests with PPIs) and the characteristics of the patients were analyzed. Results: Lansoprazole was the most commonly suspected drug with 41 patients (68.3%), followed by pantoprazole in 12 patients (20.0%), esomeprazole in 6 (10.0%), rabeprazole in 4 (6.7%), and omeprazole in 1 (1.7%). Anaphylaxis (40 patients, 66.7%) was the most common clinical presentation followed by urticaria (17 patients, 28.3%). Diagnostic skin tests with the culprit PPI were positive in 13/26 patients (50.0%). Diagnostic oral-provocation tests were negative in 6/8 patients; 5 of these 6 patients had skin test results with the culprit PPI, and all were negative. Ten patients had at least 1 cross-reactivity. Extensive cross-reactivity (between >2 PPIs) was detected in 4 patients. Conclusions: Lansoprazole was the most frequently implicated drug and anaphylaxis was the most frequent manifestation of PPI-induced hypersensitivity reactions. Physicians should be aware of the possible cross-reactivity among PPIs; however, a safe, alternative PPI can usually be detected by a thorough drug allergy workup.

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“…However, patients hypersensitive to lansoprazole showed no cross‐reactivity to omeprazole or pantoprazole. The results of skin prick tests and oral challenge tests have suggested cross‐reactivities among different PPIs 3,7,8 . These cross‐reactivities may be associated with the subtle differences in the molecular structure of the PPIs.…”

Section: Details Of the Casesmentioning

confidence: 99%

“…The results of skin prick tests and oral challenge tests have suggested cross-reactivities among different PPIs. 3,7,8 These cross-reactivities may be associated with the subtle differences in the molecular structure of the PPIs. PPIs are modified benzimidazoles with a pyridine ring, which differ in substitutions on both rings.…”

Section: Details Of the Casesmentioning

confidence: 99%