IgE mediated hypersensitivity in ageing

Delespesse, Guy; Maubeuge, J. De; Kennès, Bernard; Nicaise, R; Govaerts, André

doi:10.1111/j.1365-2222.1977.tb01436.x

Cited by 41 publications

(22 citation statements)

References 14 publications

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“…ff/., 1977;Pupil & Berna, 1976). Finally, we recently reported that the specific IgE antibody response to a subcutaneous injection of diphtheria toxoid was significantly lower in old than in young non-allergic subjects (Delespesse et al, 1977). Indeed, it has been reported that the skin response to anti-IgE antibodies or to compound 48/80, a non-specific histamine-releasing factor, is decreased in old subjects, whereas the weal and flare reaction to histamine is normal (Delespesse et ai, 1977;Pupil & Berna, 1976).…”

Section: Introductionmentioning

confidence: 97%

“…Indeed, previous studies on non-allergic humans strongly suggest that ageing is associated with a reduced ability to develop type I, IgE-mediated allergic reactions (Orren & Dowdle, 1975: Johansson, 1968Delespesse c? On the other hand, a moderate but significant ageassociated reduction of serum IgE concentration is well-documented (Orren & Dowdle, 1975;Johansson, 1968;Delespesse et al, 1977). This characteristic of the elderly is probably related to the decline of the mast cell function and the IgH antibody production.…”

Section: Introductionmentioning

confidence: 98%

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Influence of ageing on IgE‐mediated reactions in allergic patients

Hanneuse¹,

Delespesse²,

Hudson³

et al. 1978

Clin Experimental Allergy

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The influence of age and sex has been evaluated in 326 allergic patients on the following parameters: total serum IgE concentration, serum concentration of specific IgE antibodies against seventeen common allergens, mean number of positive allergens, absolute numbers of circulating eosinophils, corticosteroid dependence and response to sodium cromoglycate (DSCG). The results indicate that age and sex significantly influence the IgE antibody production in these patients. The data strongly suggests the appearance during ageing of a progressive natural desensitization. This contrasts with the increased frequency of corticosteroid-dependent cases during ageing. There is an inverse relation between age and response to DSCG therapy.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Influence of ageing on IgE‐mediated reactions in allergic patients

Hanneuse¹,

Delespesse²,

Hudson³

et al. 1978

Clin Experimental Allergy

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“…From the present results (table IV) and from the literature [11,29] there is no doubt that the lymphocyte response to PHA is reduced in old subjects. Similar conclu sions can be reached concerning the isoag glutinin titers [22,25], the serum IgE con centration [6,16] and the specific IgE anti body response [6,14]. An age-associated reduction of IgG antibody response has been described by Roberts-Thompson et al [15] in volunteers injected with Flagellin from Salmonella Adelaide.…”

Section: Discussionmentioning

confidence: 48%

Influence of Levamisole on the Immune Response of Old People

Delespesse¹,

Vrijens²,

Maubeuge³

et al. 1977

Int Arch Allergy Immunol

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Fifteen healthy people, over 70 years old, have been treated during 1 month with Levamisole at the dose of 150 mg a day, twice a week. They have been compared to 15 controls matched for age and sex. At the start of the study, each subject was injected with 0.2 ml of a diphtheria-tetanus vaccine. Levamisole had no effect on the following immune parameters known to be altered in old age: serum IgE concentration, specific IgE and IgG antibody response to diphtheria toxin, lymphocyte response to phytohemagglutinin (PHA). There was a slight and transitory effect of Levamisole on the isohemagglutinin titer. In vitro, Levamisole was weakly mitogenic for the peripheral blood lymphocytes from old and young control subjects but there was no influence on the response to PHA.

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“…Varios estudios han demostrado que la IgE sé-rica total en individuos no alérgicos disminuye con la edad, 76,77 pero la relación entre la IgE total y la enfermedad alérgica persiste en los ancianos. Al respecto se ha informado que presentan con mayor frecuencia rinitis y asma cuando las cifras de este anticuerpo se encuentran elevadas.…”

Section: Alergia Y Asmaunclassified

Senescencia del sistema inmune y alteraciones relacionadas con el asma

Vega-Robledo

Rico-Rosillo

2017

RAM

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Senescence is an irreversible process by which cells enter to a permanent cell cycle arrest with generalized molecular changes. Senescent cells remain metabolically active and most of them show a secretory phenotype; through its secretion may induce senescence or cancer in other cells. The secretory cells in the so-called transient senescence may participate in embryogenesis, tissue regeneration and immune response. The deleterious changes associated with age affect the immune system members and the immune senescence cause poor response to vaccines and susceptibility to cancer and infections. These latter are a frequent cause of asthma mostly in the elderly, the incidence is increasing in old people, and it may be related with those anatomical, physiological and immune changes caused by age, asthma chronicity and external agents. Comorbidity in the elderly worsens the ailment and hinders diagnosis, therefore, knowledge and handling of these clinical entities must be in control by the physicians responsible of the first level attention to old patients. Senescencia del sistema inmune y alteraciones relacionadas con el asma

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IgE mediated hypersensitivity in ageing

Cited by 41 publications

References 14 publications

Influence of ageing on IgE‐mediated reactions in allergic patients

Influence of ageing on IgE‐mediated reactions in allergic patients

Influence of Levamisole on the Immune Response of Old People

Senescencia del sistema inmune y alteraciones relacionadas con el asma

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