IgE myeloma: a case presentation and a review of the literature

Kairemo, Kalevi; Lindberg, Morten; Prytz, M

doi:10.1080/00365519950185472

Cited by 33 publications

(20 citation statements)

References 17 publications

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“…Testing urine for proteins is a simple way of looking for light chains; sulfosalicylic acid test rather than the dipstick is recommended because the latter often misses light chains; a negative test result makes the likelihood of Bence Jones proteinuria extremely small ( [14,19]; Robert A Kyle, personal communication). Clinical features of IgD and IgE myeloma are similar to that of other myelomas but Bence-Jones proteinuria, extramedullary involvement, lytic lesions and amyloidosis have been reported to be more frequent in IgD [26]; plasma cell leukemic presentation is common in IgE myeloma [27].…”

Section: Discussionmentioning

confidence: 79%

Old but Still Relevant: High Resolution Electrophoresis and Immunofixation in Multiple Myeloma

Misra

Mishra

Chandramohan

et al. 2015

Indian J Hematol Blood Transfus

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Introduction: High resolution electrophoresis (HRE) and immunofixation (IFX) of serum and urine are integral to the diagnostic work-up of multiple myeloma. Unusual electrophoresis patterns are common and may be misinterpreted. Though primarily the responsibility of the hematopathologist, clinicians who are responsible for managing myelomas may benefit from knowledge of these. In this review article we intend to discuss the patterns and importance of electrophoresis in present day scenario. Methods: Patterns of HRE and IFX seen in our laboratory over the past 15 years were studied. Results: Monoclonal proteins are seen on HRE as sharply defined bands, sometimes two, lying from c-to a-globulin regions on a background of normal, increased or decreased polyclonal c-globulins, showing HRE to be a rapid and dependable method of detecting M-protein in serum or urine. Immunofixation complements HRE and due to its greater sensitivity, is able to pick up small or light chain bands, not apparent on electrophoresis, including biclonal disease even when electrophoresis shows only one M-band. Special features liable to misinterpretation are discussed. Familiarity with the interpretation of the varied patterns seen in health and disease is essential for providing dependable laboratory support in the management of multiple myeloma.

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Section: Discussionmentioning

confidence: 79%

Old but Still Relevant: High Resolution Electrophoresis and Immunofixation in Multiple Myeloma

Misra

Mishra

Chandramohan

et al. 2015

Indian J Hematol Blood Transfus

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“…IgE myeloma is in fact similar to classical myeloma in sex distribution and age of onset. Of the known cases of IgE myeloma including the one in the current report, the male-to-female ratio was 20:18, and ages of these patients ranged from 38 to 80 years (Jako et al, 1997;Kairemo et al, 1999;Lloyd et al, 2003). IgE myeloma has no specific or typical symptoms and findings when compared with the other forms of MM.…”

Section: Discussionmentioning

confidence: 99%

“…The average survival from time of diagnosis in a review of 38 cases (Kairemo et al, 1999) was significantly shorter in patients with IgE myeloma (one year) than those with other forms of myeloma (30 months) (Yoshitake et al, 1976). Our patient is alive well and healthily with an 18-month complete remission up to now.…”

Section: Discussionmentioning

confidence: 99%

“…IgG and IgA myelomas are the common forms, but IgE myeloma is rare. Since the first case of IgE myeloma was reported in 1967 (Johansson and Bennich, 1967), only about 40 cases have been described in the literature (Jako et al, 1997;Kairemo et al, 1999;Lloyd et al, 2003). The prevalence of IgE myeloma is about 0.01% in all plasmocytomas (Jako et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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IgE myeloma with elevated level of serum CA125

Wang

Huang

Yang

2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To explore clinical and laboratory features and significance of detecting serum carbohydrate antigen 125 (CA125) in immunoglobulin E (IgE) multiple myeloma. Methods: We reported the clinical findings of a male patient with IgE myeloma and elevated level of serum CA125 and reviewed the literature. Results: Laboratory tests of this patient on admission showed extremely high serum IgE and CA125, a bone marrow aspirate revealed abnormal plasma cells (38.4% of nucleated cells: 16.4% mature and 22% atypical), and in bone marrow biopsy, immunoperoxidase staining showed positive cytoplasmic staining for IgE and κ light chain within the vast majority of plasma cells. Computed tomography (CT) bone scans indicated wedge shape change and compressive fracture of thoracic vertebrae, and emission computed tomography (ECT) discovered multiple punctiform aggregation of radiation in both cervical ribs and spine. The serum IgE and CA125 gradually decreased to normal limits after eight cycles of chemotherapy. This patient is alive well with an 18-month complete remission. Conclusion: We reported the first case of IgE myeloma with elevated level of serum CA125. To further evaluate clinical characteristics and significance of CA125 in IgE myeloma, more cases are needed.

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“…IgE is one of a handful of laboratory values with a logarithmic range. Monoclonal production of IgE is rarely found in plasmocytoma and has not been reported in children (17). Polyclonal increases of serum IgE in developed countries are most frequently caused by an allergen-specific IgE antibody response, as in atopic eczema/dermatitis syndrome (AEDS) (18).…”

Section: Disorders Characterized By Excessive Ige Productionmentioning

confidence: 99%