IGF-1 and IGF-1R modulate the effects of IL-4 on retinal ganglion cells survival: The involvement of M1 muscarinic receptor

Granja, Marcelo Gomes; Braga, Luis Eduardo Gomes; Oliveira, Raphael Monteiro de; Silva, Eliezer de Mello; Gonçalves-de-Albuquerque, Cassiano Felippe; Silva, Adriana Ribeiro; Castro‐Faria‐Neto, Hugo C.; Santos, Aline Araújo dos; Giestal-de-Araujo, Elizabeth

doi:10.1016/j.bbrc.2019.08.124

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…There is some evidence that IGF-I may interact with muscarinic receptors in various brain systems (Batty et al, 2004 ; Granja et al, 2019 ). Thus, we explore if the muscarinic cholinergic receptor antagonist atropine could prevent IGF-I effects in young animals.…”

Section: Resultsmentioning

confidence: 99%

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Zegarra-Valdivia

Chaves-Coira

Sevilla

et al. 2021

Front. Aging Neurosci.

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It is known that aging is frequently accompanied by a decline in cognition. Furthermore, aging is associated with lower serum IGF-I levels that may contribute to this deterioration. We studied the effect of IGF-I in neurons of the horizontal diagonal band of Broca (HDB) of young (≤6 months old) and old (≥20-month-old) mice to determine if changes in the response of these neurons to IGF-I occur along with aging. Local injection of IGF-I in the HDB nucleus increased their neuronal activity and induced fast oscillatory activity in the electrocorticogram (ECoG). Furthermore, IGF-I facilitated tactile responses in the primary somatosensory cortex elicited by air-puffs delivered in the whiskers. These excitatory effects decreased in old mice. Immunohistochemistry showed that cholinergic HDB neurons express IGF-I receptors and that IGF-I injection increased the expression of c-fos in young, but not in old animals. IGF-I increased the activity of optogenetically-identified cholinergic neurons in young animals, suggesting that most of the IGF-I-induced excitatory effects were mediated by activation of these neurons. Effects of aging were partially ameliorated by chronic IGF-I treatment in old mice. The present findings suggest that reduced IGF-I activity in old animals participates in age-associated changes in cortical activity.

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Section: Resultsmentioning

confidence: 99%

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Zegarra-Valdivia

Chaves-Coira

Sevilla

et al. 2021

Front. Aging Neurosci.

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“…IL-1β is a pro-inflammatory cytokine which features in inflammatory and infectious diseases, leading immune cell recruitment and bacterial clearance eventually (Zhang et al 2019 ). IL-4 is an anti-inflammatory cytokine, which is related to regulating immune cells, cancer and trophic responses (Granja et al 2009 ; Shamoun et al 2018 ; Oviedo-Boyso et al 2007 ) found that when cows develop bacteria-induced inflammation, the levels of pro-inflammatory cytokines like IL-1β, IL-2 and IL-6 in the body increased, and the overexpression of pro-inflammatory factor caused tissue damage. A large number of studies showed that IL-4 and IL-10 can inhibit the secretion of pro-inflammatory cytokines like IL-1β and IL-6 (Cawston et al 1996 ; Mak and Saunders 2006 ; Borghaei et al 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Broussonetia papyrifera silage on the serum indicators, hindgut parameters and fecal bacterial community of Holstein heifers

et al. 2020

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This study investigated the effects of substitution of whole corn silage (WCS) with Broussonetia papyrifera silage (BPS) in different ratios on the serum indicators, hindgut fermentation parameters (pH, ammoniacal nitrogen, and volatile fatty acids), and fecal bacterial community of Holstein heifers. Sixteen heifers (8-month-old, 220 ± 30 kg) were randomly divided into four treatments according to different BPS substitution ratios of feed basis (0%, 25%, 50%, and 75%). The experiment consisted of a 7-day preliminary feeding period and a 30-day experimental period. On the last day of the trial, the blood samples were collected from caudal vein, and the feces samples were collected from rectum. With the increasing of BPS content, the concentration of malondialdehyde (MDA) and interleukin-1β (IL-1β) in serum decreased (P < 0.05), and the immunoglobulin A (IgA) and IL-4 content of serum increased (P < 0.05); and the hindgut pH value increased (P < 0.05). 16S rRNA sequencing found that the dominant phyla were Firmicutes, Bacteroidetes, and Verrucomicrobia; and the dominant genera were Ruminococcaceae_UCG-005, Ruminococcaceae_UCG-010, and Rikenellaceae_RC9_gut_group. Linear Discriminant Analysis Effect Size (LEfSe) analysis found 12 differential operational taxonomic units (OTUs) which have strong correlation with some serum and hindgut indicators, and have the potential to be used as biomarkers. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) found that BPS have impacts on the pathways, such as carbohydrate transport and metabolism, and promotes amino acid transport and metabolism. To sum up, inclusion of BPS in heifer diets can affect serum anti-oxidant and immune indicators, fecal parameters, composition and function of fecal microorganisms in Holstein heifers.

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“…L-satropane was reported to be effective in preventing retinal neuron damage, which may be attributed to decreasing cell apoptosis and amyloid-β (Aβ) production via activation of M 1 receptor subtype [ 87 ]. Moreover, in an in vivo study, the M 1 muscarinic receptor was reported to exert protective effects on RGCs via activation of insulin growth factor 1 (IGF-1) and insulin growth factor 1 receptor (IGF-1R) [ 88 ]. Additionally, activation of PKC delta was suggested to regulate neurotrophin levels by M 1 muscarinic receptor activation ultimately leading to an increase in RGCs’ survival in vitro in the retina [ 89 , 90 ].…”

Section: Functional Roles Of Individual Machr Subtypes In the Retinamentioning

confidence: 99%

Muscarinic Acetylcholine Receptors in the Retina—Therapeutic Implications

Ruan

Patzak

Pfeiffer

et al. 2021

IJMS

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Muscarinic acetylcholine receptors (mAChRs) belong to the superfamily of G-protein-coupled receptors (GPCRs). The family of mAChRs is composed of five subtypes, M1, M2, M3, M4 and M5, which have distinct expression patterns and functions. In the eye and its adnexa, mAChRs are widely expressed and exert multiple functions, such as modulation of tear secretion, regulation of pupil size, modulation of intraocular pressure, participation in cell-to-cell signaling and modula-tion of vascular diameter in the retina. Due to this variety of functions, it is reasonable to assume that abnormalities in mAChR signaling may contribute to the development of various ocular diseases. On the other hand, mAChRs may offer an attractive therapeutic target to treat ocular diseases. Thus far, non-subtype-selective mAChR ligands have been used in ophthalmology to treat dry eye disease, myopia and glaucoma. However, these drugs were shown to cause various side-effects. Thus, the use of subtype-selective ligands would be useful to circumvent this problem. In this review, we give an overview on the localization and on the functional role of mAChR subtypes in the eye and its adnexa with a special focus on the retina. Moreover, we describe the pathophysiological role of mAChRs in retinal diseases and discuss potential therapeutic approaches.

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IGF-1 and IGF-1R modulate the effects of IL-4 on retinal ganglion cells survival: The involvement of M1 muscarinic receptor

Cited by 8 publications

References 28 publications

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Effect of Broussonetia papyrifera silage on the serum indicators, hindgut parameters and fecal bacterial community of Holstein heifers

Muscarinic Acetylcholine Receptors in the Retina—Therapeutic Implications

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