IGF1 Gene Polymorphism in Selected Species of the Canidae Family

Abstract

The gene IGF1 has been shown to have a signifi cant infl uence on the size of individuals, including animals of the Canidae family. In this study we determined SNP mutations of the IGF1 gene in dogs, raccoon dogs and farmed and free-living red foxes from Poland and Canada. No SNP mutations were noted in dogs or raccoon dogs, but a total of 14 single nucleotide polymorphisms were identifi ed in foxes, including 12 substitutions, as well as one new mutation missense variant (exon 6) in wild Polish foxes and one synonymous mutation variant in wild foxes from Canada. We identifi ed specifi c SNP profi les characteristic only for farmed foxes and only for wild foxes, as well as specifi c SNP profi les or wild foxes from North America (Canada) and from Europe (Poland).

The effect of a fibroblast growth factor, insulin-like growth factor, growth hormone, and Biolaminin 521 LN on the proliferative activity of cat stem cells

“…The structure of IGF-1 (somatomedin C) is similar to that of insulin, which is why this growth factor is able to bind the insulin receptor (Jakubczak et al 2014;Jakubczak et al 2017). It is also a mitogen for a majority of cells and can act as insulin (Niedźwiedzka 2000).…”