IGF2BP2 polymorphisms as genetic biomarkers for either schizophrenia or type 2 diabetes mellitus: A case-control study

Sargazi, Saman; Nia, Milad Heidari; Shahroudi, Mahdieh Jafari; Jahantigh, Danial; Shakiba, Mansour

doi:10.1016/j.genrep.2020.100680

Cited by 18 publications

(14 citation statements)

References 40 publications

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“…The two selected polymorphisms (rs2868370 and rs2868371) are located in the promoter of HSPB1 gene. There is evidence that suggests that the SNPs that are located within the promoter regions have a high potential to alter gene expression by affecting the binding of the transcription factors [ 42 , 43 ]. The functionality of the rs2868371 was confirmed in a previous study.…”

Section: Discussionmentioning

confidence: 99%

HSPB1 Gene Variants and Schizophrenia: A Case-Control Study in a Polish Population

et al. 2022

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Schizophrenia (SCZ) is a severe psychiatric disorder that has a significant genetic component. HSPB1 (HSP27) is known for its neuroprotective functions under stress conditions and appears to play an important role during the development of the central nervous system, which is in agreement with the neurodevelopmental hypothesis of SCZ. The aim of the present case-control study was to investigate whether HSPB1 variants contribute to the risk and clinical features (age of onset, symptoms, and suicidal behavior) of SCZ in a Polish population. To the best of our knowledge, this is the first study that investigated the association between the HSPB1 polymorphisms and SCZ. Three SNPs of HSPB1 (rs2868370, rs2868371, and rs7459185) were genotyped in a total of 1082 (403 patients and 679 controls) unrelated subjects using TaqMan assays. The results showed that the genotypes, alleles, and haplotypes of the three SNPs were not significantly different between the schizophrenic patients and healthy controls either in the overall analysis or in the gender-stratified analysis (all p > 0.05 ). However, we did find a significant effect of the rs2868371 genotype on the age of onset, negative symptoms, and disorganized symptoms in the five-factor model of PANSS (all p < 0.01 ). Post hoc comparisons showed that carriers of the rs2868371 G/G genotype had significantly higher negative and disorganized factor scores than those with the C/G and C/C genotypes, respectively. Further investigations with other larger independent samples are required to confirm our findings and to better explore the effect of the HSPB1 polymorphisms on the risk and symptomatology of SCZ.

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Section: Discussionmentioning

confidence: 99%

HSPB1 Gene Variants and Schizophrenia: A Case-Control Study in a Polish Population

et al. 2022

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“…These results are affected by a small recessive genotype and inadequate statistical power in certain models. In addition, certain researches have shown that recessive IGF2BP2 polymorphisms associate with T2DM risk [25], [26], although others found this risk with dominant genetic models [27], [28].…”

Section: Discussionmentioning

confidence: 99%

Insulin-like Growth Factor-2 Binding Protein-2 Gene Polymorphisms in Iraqi Patients with Type 2 Diabetes Mellitus

Falih

Khodair²,

Mohammed³

et al. 2022

Open Access Maced J Med Sci

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Background: Diabetes mellitus type2 (T2DM) represent a hyperglycemia causing metabolic disease which exists in the peripheral tissues due to incomplete pancreatic insulin secretion or insulin resistance. IGF2BP2 is a protein that is involved in embryogenesis and pancreatic development. Genetic association researches had suggested that the single nucleotide polymorphisms (SNP) spanning IGF2BP2 gene are associated with the progression as well as development of the T2DM. Aim: This study aims to evaluate the association of IGF2BP2 gene polymorphisms (rs4402960 & rs1470579) with T2DM in a sample of Iraqi individuals. Methods: A case-control study has been conducted on 800 participants, they were divided to two equal groups, which are a healthy control group (400) and type 2 diabetic patients (400). Fast blood sugar (FBS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and HbA1c] measured suitable for both participant groups. IGF2BP2 gene has been genotyped for polymorphisms; rs4402960 and rs1470579 by using the PCR-RFLP technique. Results: There is significant changes in the biochemical parameters in patients group when compared to the control group.The SNP rs4402960 show minor allele frequency of T allele considerably different between the two participating groups (p 0.0013) with 33.6 % in T2DM group. Homo-variant TT shows a significant p <0.0001) odd ratio (4.5) as codominant type. Similarly, dominant and recessive models exert significant (0.02 & <0.0001 respectively) adjusted odd ratio (1.45 & 4.14 respectively). The rs1470579 SNP show a significant (0.024) risk (1.28) of C allele in the patients group than in A allele. The CC genotype in codominant and recessive models show significant (0.03) odd ratio differences (2.03 & 1.96 respectively. The rs1470579 SNP exerts significant differences as codominant model in biochemical features of BMI, FBG, Tgs, VLDL-C, insulin and HOMA-IR. The study power of rs4402960 is 69.5% and rs1470579 is 34.1%. Conclusion: This study confirmed the association of rs4402960 as codominant, dominant and recessive with T2DM significantly. However, rs1470579 is associate as recessive model with T2DM in Iraqi population.

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“… 28 IGF2BP2 rs11705701 and rs1470579 gene polymorphisms may be associated with T2DM. 29 Case-control study showed that functional miR-143/145 variants may affect the risk of T2DM. 30 In addition, the SIRT1 functional variants rs12778366 significantly increased the risk of T2DM, and the rs3758391 was associated with a reduced risk of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Association of CYP7A1 and CYP2E1 Polymorphisms with Type 2 Diabetes in the Chinese Han Populations

Zhang¹,

Tang²,

Wang³

et al. 2022

PGPM

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Background Type 2 diabetes mellitus (T2DM) is caused by diverse environmental and genetic risk factors. Previous studies have reported that cytochrome P450 ( CYP ) is a promising gene for T2DM. Therefore, we aimed to determine the effects of CYP7A1 and CYP2E1 polymorphisms on T2DM susceptibility among the Chinese Han population. Methods A case-control study was conducted to assess the potential relationship of four polymorphisms (rs8192879, rs12542233, rs2070672 and rs2515641) with T2DM susceptibility in the Chinese population, involving 512 T2DM patients and 515 age- and gender-matched healthy individuals. We used the Agena MassARRAY platform to detect CYP7A1 and CYP2E1 polymorphisms. The relationship between genetic polymorphisms and T2DM risk was evaluated using odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models. Results After adjusting for age and gender, rs12542233 in the CYP7A1 gene was significantly associated with decreased T2DM risk (recessive: OR = 0.67, 95% CI = 0.49–0.91, p = 0.012; after FDR correction, p = 0.048). The CYP7A1 rs12542233 was associated with a reduced risk of T2DM in people over 59 years of age ( p = 0.010). In the population with BMI ≤ 24 kg/m 2 , CYP7A1 rs12542233 was associated with an increased risk of T2DM ( p < 0.05). In the population with BMI > 24 kg/m 2 , CYP2E1 rs2515641 can significantly reduce the risk of T2DM ( p < 0.05). And rs8192879, rs2070672 and rs2515641 could significantly increase the risk of diabetes retinopathy in T2DM patients ( p < 0.05). Furthermore, the T rs8192879 C rs12542233 haplotype was significantly associated with T2DM ( p = 0.019). Conclusion CYP7A1 and CYP2E1 polymorphisms may contribute to T2DM susceptibility in the Chinese Han population, especially in stratified analysis.

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IGF2BP2 polymorphisms as genetic biomarkers for either schizophrenia or type 2 diabetes mellitus: A case-control study

Cited by 18 publications

References 40 publications

HSPB1 Gene Variants and Schizophrenia: A Case-Control Study in a Polish Population

HSPB1 Gene Variants and Schizophrenia: A Case-Control Study in a Polish Population

Insulin-like Growth Factor-2 Binding Protein-2 Gene Polymorphisms in Iraqi Patients with Type 2 Diabetes Mellitus

Association of CYP7A1 and CYP2E1 Polymorphisms with Type 2 Diabetes in the Chinese Han Populations

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